Acute renal failure caused by acute monofluoroacetate poisoning.
NaFA produces toxic effects by metabolic conversion to fluorocitrate, inhibits Krebs' cycle and the formation of ATP, reduces energy supply to cells, and thus causes cellular dysfunction or degeneration. All body cells are potentially affected, although with different sensitivity. Acute renal failure was found in three out of our five cases, and two were in frank uremia. The ARF was reversible and may be either oliguric or non-oliguric. The causes of ARF were not apparent, but direct nephropathy or some other factors might be involved in the pathogenesis of ARF.[1]References
- Acute renal failure caused by acute monofluoroacetate poisoning. Chung, H.M. Veterinary and human toxicology. (1984) [Pubmed]
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