Disease relevance of Monofluoressigsaures natrium

• Ammonia and disinhibition in cat motor cortex by ammonium acetate, monofluoroacetate and insulin-induced hypoglycemia [1].
• Biosynthesis of fluorothreonine and fluoroacetic acid by the thienamycin producer, Streptomyces cattleya [2].
• Acute renal failure caused by acute monofluoroacetate poisoning [3].
• These data demonstrate the presence of SMFA in the water-soluble fraction of P. marcgravii leaves and show that monofluoroacetate is the active principle responsible for the signs and symptoms of acute intoxication [4].
• Effect of acidosis, alkalosis and monofluoroacetate administration on citrate and ATP content of rat renal medulla and papilla [5].

High impact information on Monofluoressigsaures natrium

• A reduction of IPSCs was also observed following application of monofluoroacetic acid, a substance acting specifically on glial cells [6].
• GSTZ also catalyzed the biotransformation of fluoroacetic acid to S-(carboxymethyl)glutathione, and of (R,S)-2-bromopropionic acid, (R)-, (S)-, and (R,S)-2-chloropropionic acid, and (R, S)-2-iodopropionic acid, but not (R,S)-2-fluoropropionic acid, to S-(alpha-methylcarboxymethyl)glutathione; and of 2, 2-dichloropropionic acid to pyruvate [7].
• Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cord [8].
• The effects of the metabolic inhibitors 2-deoxy-d-glucose and monofluoroacetate on intracellular ion concentrations and Na transport rate were investigated in the isolated frog skin epithelium of Rana pipiens [9].
• The effects of monofluoroacetate (FAC) on suspensions of isolated rat kidney tubules were investigated [10].

Associations of Monofluoressigsaures natrium with other chemical compounds

• Ethyl acetate is removed by volatilization from fluoroacetic acid which is retained as the triethanolammonium fluoroacetate salt [11].
• A rapid method is described for the extraction and identification of fluoroacetamide and fluoroacetic acid from tissues, by gas chromatography, using a mass spectrometer in the multiple ion monitoring mode as the detector [12].
• The fluoroacetic acid in the distillate is derivatized with pentafluorobenzyl bromide to form pentafluorobenzyl fluoroacetate which is measured by electron capture gas-liquid chromatography [13].

Analytical, diagnostic and therapeutic context of Monofluoressigsaures natrium

• A simple and sensitive gas chromatography and gas chromatography-mass spectrometry (GC-MS) procedure has been developed for fluoroacetic acid (FA) and phenoxy acid herbicides (PAHs) via triphasal extractive pentafluorobenzylation [14].
• A simple isocratic high-performance liquid chromatographic (HPLC) method for the quantitative analysis of monofluoroacetic acid (MFA), the toxic substance of Dichapetalum cymosum, in plant material, rumen contents (gastric contents), and liver samples is described [15].

References