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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The isotretinoin teratogen syndrome.

Two infants with prominent frontal bossing, hydrocephalus, microphthalmia, and small, malformed, low-set, undifferentiated ears were born to mothers who had taken isotretinoin in the first trimester of pregnancy. A Dandy-Walker malformation, microcephaly, hypertelorism, small ear canals, cleft palate, small mouth, and congenital heart disease were also observed. Isotretinoin is a potent teratogen in man; maternal ingestion early in pregnancy leads to a distinct clinical pattern of anomalies.[1]

References

  1. The isotretinoin teratogen syndrome. Benke, P.J. JAMA (1984) [Pubmed]
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