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Chemical Compound Review

Tri-Luma     3,7-dimethyl-9-(2,6,6- trimethyl-1...

Synonyms: AG-F-61922, AG-G-59464, AG-L-64431, KBioGR_000051, KBioGR_000215, ...
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Disease relevance of Vitamin A acid


Psychiatry related information on Vitamin A acid


High impact information on Vitamin A acid


Chemical compound and disease context of Vitamin A acid


Biological context of Vitamin A acid


Anatomical context of Vitamin A acid


Associations of Vitamin A acid with other chemical compounds


Gene context of Vitamin A acid

  • However, the presence of a neutralizing Ab to IL-4 (11B11) during MBP-specific LNC activation in vitro did not reverse the inhibition of encephalitogenicity caused by tRA [26].
  • Mean PAI-1 antigen and PAI activity in 9 a.m. plasma samples were non-significantly higher during isotretinoin than during placebo treatment [28].
  • These data indicate that MMP and TIMP of epithelial origin may be involved in acne pathogenesis, and that isotretinoin-induced reduction in MMP-9 and -13 may contribute to the therapeutic effects of the agent in acne [29].
  • Isotretinoin inhibited the arachidonic acid-induced secretion and mRNA expression of proMMP-2 and -9 in both cell types and of MMP-13 in HaCaT keratinocytes [29].
  • Influence of aging, localization, glucocorticoids and isotretinoin on matrix metalloproteases 2 (MMP-2) and 9 (MMP-9) in suction blister fluids [30].

Analytical, diagnostic and therapeutic context of Vitamin A acid


  1. Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis. Lippman, S.M., Batsakis, J.G., Toth, B.B., Weber, R.S., Lee, J.J., Martin, J.W., Hays, G.L., Goepfert, H., Hong, W.K. N. Engl. J. Med. (1993) [Pubmed]
  2. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. Hong, W.K., Lippman, S.M., Itri, L.M., Karp, D.D., Lee, J.S., Byers, R.M., Schantz, S.P., Kramer, A.M., Lotan, R., Peters, L.J. N. Engl. J. Med. (1990) [Pubmed]
  3. Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin. Kraemer, K.H., DiGiovanna, J.J., Moshell, A.N., Tarone, R.E., Peck, G.L. N. Engl. J. Med. (1988) [Pubmed]
  4. Functional brain imaging alterations in acne patients treated with isotretinoin. Bremner, J.D., Fani, N., Ashraf, A., Votaw, J.R., Brummer, M.E., Cummins, T., Vaccarino, V., Goodman, M.M., Reed, L., Siddiq, S., Nemeroff, C.B. The American journal of psychiatry. (2005) [Pubmed]
  5. Isotretinoin treatment of a woman with bipolar disorder. Cott, A.D., Wisner, K.L. The Journal of clinical psychiatry. (1999) [Pubmed]
  6. Ocular adverse effects associated with systemic medications : recognition and management. Santaella, R.M., Fraunfelder, F.W. Drugs (2007) [Pubmed]
  7. Hypersomnia associated with isotretinoin in a patient with recurrent major depressive disorder and acne vulgaris. Shehi, G.M., Bryson, W.J. Sleep. (2004) [Pubmed]
  8. Increased use of mental health services related to Isotretinoin treatment: a 5-year analysis. Friedman, T., Wohl, Y., Knobler, H.Y., Lubin, G., Brenner, S., Levi, Y., Barak, Y. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2006) [Pubmed]
  9. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. Lotan, R., Xu, X.C., Lippman, S.M., Ro, J.Y., Lee, J.S., Lee, J.J., Hong, W.K. N. Engl. J. Med. (1995) [Pubmed]
  10. Isotretinoin for juvenile chronic myelogenous leukemia. Pui, C.H., Aricò, M. N. Engl. J. Med. (1995) [Pubmed]
  11. A pregnancy-prevention program in women of childbearing age receiving isotretinoin. Mitchell, A.A., Van Bennekom, C.M., Louik, C. N. Engl. J. Med. (1995) [Pubmed]
  12. A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia. Castleberry, R.P., Emanuel, P.D., Zuckerman, K.S., Cohn, S., Strauss, L., Byrd, R.L., Homans, A., Chaffee, S., Nitschke, R., Gualtieri, R.J. N. Engl. J. Med. (1994) [Pubmed]
  13. Retinoid protection against x-ray-induced chromatid damage in human peripheral blood lymphocytes. Sanford, K.K., Parshad, R., Price, F.M., Tarone, R.E., Kraemer, K.H. J. Clin. Invest. (1992) [Pubmed]
  14. Cutaneous T-cell lymphoma and calcitriol and isotretinoin treatment. Thomsen, K. Lancet (1995) [Pubmed]
  15. The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration. Gollapalli, D.R., Rando, R.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  16. Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis. Lippman, S.M., Benner, S.E., Hong, W.K. Cancer Res. (1994) [Pubmed]
  17. 13-cis retinoic acid and complete androgen blockade in advanced hormone-naive prostate cancer patients: report of a phase II randomized study. Ferrari, A.C., Stone, N., Stock, R., Bednar, M., Esseesse, I., Singh, H., Baldwin, Y., Mandeli, J. J. Clin. Oncol. (2002) [Pubmed]
  18. The isotretinoin teratogen syndrome. Benke, P.J. JAMA (1984) [Pubmed]
  19. Adjuvant effect of vitamin A palmitate and analogs on cell-mediated immunity. Athanassiades, T.J. J. Natl. Cancer Inst. (1981) [Pubmed]
  20. Limb reduction deformities in child exposed to isotretinoin in utero on gestation days 26-40 only. McBride, W.G. Lancet (1985) [Pubmed]
  21. Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. Sieving, P.A., Chaudhry, P., Kondo, M., Provenzano, M., Wu, D., Carlson, T.J., Bush, R.A., Thompson, D.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  22. Retinoic acid embryopathy. Lammer, E.J., Chen, D.T., Hoar, R.M., Agnish, N.D., Benke, P.J., Braun, J.T., Curry, C.J., Fernhoff, P.M., Grix, A.W., Lott, I.T. N. Engl. J. Med. (1985) [Pubmed]
  23. 13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice. Crandall, J., Sakai, Y., Zhang, J., Koul, O., Mineur, Y., Crusio, W.E., McCaffery, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  24. Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog. Zhang, Y., Dawson, M.I., Ning, Y., Polin, L., Parchment, R.E., Corbett, T., Mohamed, A.N., Feng, K.C., Farhana, L., Rishi, A.K., Hogge, D., Leid, M., Peterson, V.J., Zhang, X.K., Mohammad, R., Lu, J.S., Willman, C., VanBuren, E., Biggar, S., Edelstein, M., Eilender, D., Fontana, J.A. Blood (2003) [Pubmed]
  25. p53 and retinoid chemoprevention of oral carcinogenesis. Lippman, S.M., Shin, D.M., Lee, J.J., Batsakis, J.G., Lotan, R., Tainsky, M.A., Hittelman, W.N., Hong, W.K. Cancer Res. (1995) [Pubmed]
  26. Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. Racke, M.K., Burnett, D., Pak, S.H., Albert, P.S., Cannella, B., Raine, C.S., McFarlin, D.E., Scott, D.E. J. Immunol. (1995) [Pubmed]
  27. Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis. Morath, C., Dechow, C., Lehrke, I., Haxsen, V., Waldherr, R., Floege, J., Ritz, E., Wagner, J. J. Am. Soc. Nephrol. (2001) [Pubmed]
  28. Effect of isotretinoin on endogenous tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in humans. Wallnöfer, A.E., van Griensven, J.M., Schoemaker, H.C., Cohen, A.F., Lambert, W., Kluft, C., Meijer, P., Kooistra, T. Thromb. Haemost. (1993) [Pubmed]
  29. Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. Papakonstantinou, E., Aletras, A.J., Glass, E., Tsogas, P., Dionyssopoulos, A., Adjaye, J., Fimmel, S., Gouvousis, P., Herwig, R., Lehrach, H., Zouboulis, C.C., Karakiulakis, G. J. Invest. Dermatol. (2005) [Pubmed]
  30. Influence of aging, localization, glucocorticoids and isotretinoin on matrix metalloproteases 2 (MMP-2) and 9 (MMP-9) in suction blister fluids. Kylmäniemio, M., Autio, P., Oikarinen, A. Arch. Dermatol. Res. (1995) [Pubmed]
  31. Toxicity of isotretinoin in a chemoprevention trial to prevent second primary tumors following head and neck cancer. Benner, S.E., Pajak, T.F., Stetz, J., Lippman, S.M., Hong, W.K., Schantz, S.P., Gallagher, M.J., Shenouda, G. J. Natl. Cancer Inst. (1994) [Pubmed]
  32. Long-term therapy with low-dose isotretinoin for prevention of basal cell carcinoma: a multicenter clinical trial. Isotretinoin-Basal Cell Carcinoma Study Group. Tangrea, J.A., Edwards, B.K., Taylor, P.R., Hartman, A.M., Peck, G.L., Salasche, S.J., Menon, P.A., Benson, P.M., Mellette, J.R., Guill, M.A. J. Natl. Cancer Inst. (1992) [Pubmed]
  33. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Radu, R.A., Mata, N.L., Nusinowitz, S., Liu, X., Sieving, P.A., Travis, G.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  34. The effect of isotretinoin in six patients with cutaneous T-cell lymphoma. Neely, S.M., Mehlmauer, M., Feinstein, D.I. Arch. Intern. Med. (1987) [Pubmed]
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