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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

T and B lymphocyte subsets in fenoprofen nephropathy.

Renal failure due to combined acute interstitial nephritis and minimal-change glomerulopathy is reported in two patients after fenoprofen therapy. In the interstitial infiltrates, T lymphocytes predominated over B lymphocytes in a ratio of four to one. The majority of B lymphocytes present were IgE-bearing cells. Among the T cells, the ratio of cytotoxic/suppressor cells to helper-inducer cells was three to one. Repeated renal biopsy in one patient after steroid-induced clinical remission demonstrated resolution of the inflammatory infiltrate and restoration of normal glomerular foot processes. The theoretic and practical implications of these findings are discussed.[1]


  1. T and B lymphocyte subsets in fenoprofen nephropathy. Stachura, I., Jayakumar, S., Bourke, E. Am. J. Med. (1983) [Pubmed]
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