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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In vivo labelling in several rat tissues of 'peripheral type' benzodiazepine binding sites.

'Peripheral type' benzodiazepine binding sites in several rat tissues were labelled by intravenous injection of [3H]PK 11195 and [3H] RO5 -4864. Binding was saturable in all tissues studied and regional distribution paralleled the in vitro binding. A similar potency order of displacing compounds was found in vivo and in vitro PK 11195 greater than PK 11211 greater than RO5 -4864 greater than diazepam greater than dipyridamole greater than clonazepam. These results demonstrate the feasibility of using this technique to examine the effects of pharmacological manipulation on the binding sites in their native state. However some properties (broader maximum during time course, higher percentage of particulate binding in the brain and independence of temperature) make [3H]PK 11195 the most suitable ligand for this kind of studies.[1]


  1. In vivo labelling in several rat tissues of 'peripheral type' benzodiazepine binding sites. Benavides, J., Guilloux, F., Rufat, P., Uzan, A., Renault, C., Dubroeucq, M.C., Gueremy, C., Le Fur, G. Eur. J. Pharmacol. (1984) [Pubmed]
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