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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A practical procedure for testing DNA damage in vivo, proposed for a pre-screening of chemical carcinogens.

The alkaline elution method was adapted to the evaluation of DNA damage induced in vivo through a practical and reliable microfluorometric procedure, without any need for tissue pre-labeling. The DNA damage induced in vivo by treatment with a single dose of N-nitrosodimethylamine (DMNA), N-methyl-N-nitroso-urea (MNU), 1,2-dimethylhydrazine (DMH) or cycasin has been detected in different organs of mice or rats. The results obtained are rather consistent with the organotropism of these carcinogens, and show a satisfactory dose dependent of DNA damage. DMH and cycasin, both negative in the Ames' Salmonella/microsome mutagenicity test, are clearly positive with in vivo DNA damage/alkaline elution assay. This latter method, complemented with other short-term tests, may play a useful role in the pre-screening of chemical carcinogens.[1]

References

  1. A practical procedure for testing DNA damage in vivo, proposed for a pre-screening of chemical carcinogens. Parodi, S., Taningher, M., Santi, L., Cavanna, M., Sciaba, L., Maura, A., Brambilla, G. Mutat. Res. (1978) [Pubmed]
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