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Chemical Compound Review

CCRIS 3455     1,1-dimethylhydrazine; 1,2-dimethylhydrazine

Synonyms: LS-194135, AC1L1W2A, Hydrazine, dimethyl-
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Disease relevance of CCRIS 3455


Psychiatry related information on CCRIS 3455


High impact information on CCRIS 3455


Chemical compound and disease context of CCRIS 3455


Biological context of CCRIS 3455


Anatomical context of CCRIS 3455

  • We evaluated certain histochemical tests for their ability to detect premalignant mucosa in the dimethylhydrazine model of colonic carcinogenesis [22].
  • Biweekly colonoscopic biopsies of the descending colon were performed for 29 wk in control and dimethylhydrazine-treated rats [22].
  • Normal-appearing intestinal mucosa from control and treated animals and DMH-induced intestinal tumors were assayed for JNK and ERK activity using solid phase in vitro kinase assays [23].
  • Mucosal atrophy and focal dysplasia were present more frequently in specimens taken from the rectum (but not the splenic flexure) of dimethylhydrazine-treated animals than of control animals, but there was no correlation between the histochemical markers and either atrophy or dysplasia [22].
  • In the present report cell proliferation was measured by a stathmokinetic method in the crypt epithelium of the jejunum and colon of normal rats and in dimethylhydrazine-induced colonic tumors [24].

Associations of CCRIS 3455 with other chemical compounds

  • The absence of gross bowel tumors in animals given DMH was unexpected but may be related to the levels of cholesterol and fiber in the diets, since these factors are reported to influence the effects of DMH [25].
  • The expression of these antigens was similar in the non-lymphoid-associated normal colonic mucosa of the untreated, EDTA-treated, and DMH-treated rats [26].
  • Both the activity and the response to phospholipase C and to mercaptans in DMH-induced tumors resembled that of fetal gut, while those in abnormal appearing DMH-treated jejunum were intermediate between normal control of the same age and tumor [27].
  • Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate [20].
  • The highest incidence of cell death occurred 4-5 h after treatment with NEU, NMU and DMH and at 6 h after NDMA [28].

Gene context of CCRIS 3455

  • In summary, alterations in the beta-catenin expression and cellular localisation in the DMH-induced tumours are similar to those seen inhuman sporadic colorectal tumours [29].
  • Comparison of Gpx2 gene expression in three pairs of C57BL/6Ha and ICR/Ha mice which are respectively resistant and sensitive to dimethylhydrazine-induced colon cancer, we found a higher Gpx2 mRNA level in C57BL/6Ha colon than ICR/Ha colon [30].
  • RESULTS: There was little or no difference in JNK and ERK activity in hyperproliferative mucosa from DMH-treated animals compared with normal mucosa from control animals [23].
  • Transformed colonies were merged in soft-agarose medium after immortalized gastric epithelial cells were transfected with recombinant pLHCX retrovirus with cagA and/or dimethylhydrazine [31].
  • These data suggest that in the dimethylhydrazine rat model of colorectal cancer, the Apc gene is mutated in early stages, albeit to a lesser degree than observed in human colorectal cancer, whereas the mutational hot spot of the p53 gene for human colorectal cancer is not commonly mutated [16].

Analytical, diagnostic and therapeutic context of CCRIS 3455


  1. Effect of BCG on dimethylhydrazine induction of colon tumors in rats. Rogers, A.E., Gildin, J. J. Natl. Cancer Inst. (1975) [Pubmed]
  2. Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat. Yamada, K., Yoshitake, K., Sato, M., Ahnen, D.J. Gastroenterology (1992) [Pubmed]
  3. Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats. Jacobs, M.M., Forst, C.F., Beams, F.A. Cancer Res. (1981) [Pubmed]
  4. Proliferative characteristics of chronic crypt cells in C57BL/6J and A/J mice as predictors of subsequent tumor formation. Glickman, L.T., Suissa, S., Fleiszer, D.M. Cancer Res. (1987) [Pubmed]
  5. Cytotoxicity of 5,6-dihydroxytryptamine in dimethylhydrazine-induced carcinomas of rat colon. Tutton, P.J., Barkla, D.H. Cancer Res. (1977) [Pubmed]
  6. Lactobacillus- and bifidobacterium-mediated antigenotoxicity in the colon of rats. Pool-Zobel, B.L., Neudecker, C., Domizlaff, I., Ji, S., Schillinger, U., Rumney, C., Moretti, M., Vilarini, I., Scassellati-Sforzolini, R., Rowland, I. Nutrition and cancer. (1996) [Pubmed]
  7. Gene interaction and single gene effects in colon tumour susceptibility in mice. van Wezel, T., Stassen, A.P., Moen, C.J., Hart, A.A., van der Valk, M.A., Demant, P. Nat. Genet. (1996) [Pubmed]
  8. Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: influence of subsequent butylated hydroxyanisole treatment. Moore, M.A., Thamavit, W., Ito, N. J. Natl. Cancer Inst. (1987) [Pubmed]
  9. Differential susceptibility of inbred mouse strains forecast by acute colonic proliferative response to methylazoxymethanol. Deschner, E.E., Long, F.C., Hakissian, M., Cupo, S.H. J. Natl. Cancer Inst. (1984) [Pubmed]
  10. Effect of embryonic tissue immunization on chemically induced gastrointestinal tumors in rats. I. Can embryonic antigens act as rejection antigens? Bansal, B.R., Mark, R., Rhoads, J.E., Bansal, S.C. J. Natl. Cancer Inst. (1978) [Pubmed]
  11. Inhibition of dimethylhydrazine-induced neoplasia of the large intestine by disulfiram. Wattenberg, L.W. J. Natl. Cancer Inst. (1975) [Pubmed]
  12. Premalignant alterations in the glycosphingolipid composition of colonic epithelial cells of rats treated with 1,2-dimethylhydrazine. Dahiya, R., Dudeja, P.K., Brasitus, T.A. Cancer Res. (1987) [Pubmed]
  13. The mode of growth and compartmentalization of neoplastic glands during experimental colon carcinogenesis. Chang, W.W. Am. J. Pathol. (1986) [Pubmed]
  14. Dietary cholesterol deprivation improves survival and reduces incidence of metastatic colon cancer in dimethylhydrazine-pretreated rats. Cruse, J.P., Lewin, M.R., Clark, C.G. Gut (1982) [Pubmed]
  15. Combination chemotherapy with 5-fluorouracil (5FU) and 1,3-bis(2-chloro-ethyl)-1-nitrosourea (BCNU) prolongs survival of rats with dimethylhydrazine-induced colon cancer. Danzi, M., Lewin, M.R., Cruse, J.P., Clark, C.G. Gut (1983) [Pubmed]
  16. The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. Sohn, K.J., Puchyr, M., Salomon, R.N., Graeme-Cook, F., Fung, L., Choi, S.W., Mason, J.B., Medline, A., Kim, Y.I. Carcinogenesis (1999) [Pubmed]
  17. Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon. Terpstra, O.T., Dahl, E.P., Williamson, R.C., Ross, J.S., Malt, R.A. Gastroenterology (1981) [Pubmed]
  18. Amplification and elevated expression of c-myc in a chemically induced mouse colon tumor. Yander, G., Halsey, H., Kenna, M., Augenlicht, L.H. Cancer Res. (1985) [Pubmed]
  19. The incidence of aberrant crypt foci and colonic carcinoma in dimethylhydrazine-treated rats varies in a site-specific manner and depends on tumor histology. Park, H.S., Goodlad, R.A., Wright, N.A. Cancer Res. (1997) [Pubmed]
  20. Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate. Kim, Y.I., Pogribny, I.P., Salomon, R.N., Choi, S.W., Smith, D.E., James, S.J., Mason, J.B. Am. J. Pathol. (1996) [Pubmed]
  21. Elevated expression of an endogenous retroviral long terminal repeat in a mouse colon tumor. Augenlicht, L.H., Kobrin, D., Pavlovec, A., Royston, M.E. J. Biol. Chem. (1984) [Pubmed]
  22. Serial observations of colonic carcinogenesis in the rat. Premalignant mucosa binds Ulex europeus agglutinin. Shioda, Y., Brown, W.R., Ahnen, D.J. Gastroenterology (1987) [Pubmed]
  23. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Licato, L.L., Keku, T.O., Wurzelmann, J.I., Murray, S.C., Woosley, J.T., Sandler, R.S., Brenner, D.A. Gastroenterology (1997) [Pubmed]
  24. Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors. Tutton, P.J., Barkla, D.H. Cancer Res. (1986) [Pubmed]
  25. Effects of dietary fat on incidence of spontaneous and induced cancer in mice. Brown, R.R. Cancer Res. (1981) [Pubmed]
  26. Tumor-associated antigens common to humans and chemically induced colonic tumors of the rat. Shetye, J.D., Rubio, C.A., Harmenberg, U., Ware, J., Duvander, A., Mellstedt, H.T. Cancer Res. (1990) [Pubmed]
  27. Biochemical changes in premalignant intestines. Salser, J.S., Ball, W.J., Balis, M.E. Cancer Res. (1976) [Pubmed]
  28. Target cells for the cytotoxic effects of carcinogens in the murine small bowel. Li, Y.Q., Fan, C.Y., O'Connor, P.J., Winton, D.J., Potten, C.S. Carcinogenesis (1992) [Pubmed]
  29. Abnormalities of the cadherin-catenin complex in chemically-induced colo-rectal carcinogenesis. Tucker, E., Buda, A., Janghra, B., Cpoad, J., Moorghan, M., Havler, M., Dettmar, P., Pignatelli, M. The Proceedings of the Nutrition Society. (2003) [Pubmed]
  30. Expression and chromosomal mapping of mouse Gpx2 gene encoding the gastrointestinal form of glutathione peroxidase, GPX-GI. Chu, F.F., Esworthy, R.S., Ho, Y.S., Bermeister, M., Swiderek, K., Elliott, R.W. Biomed. Environ. Sci. (1997) [Pubmed]
  31. Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway. Zhu, Y., Zhong, X., Zheng, S., Du, Q., Xu, W. Oncogene (2005) [Pubmed]
  32. Selective necrosis in dimethylhydrazine-induced rat colon tumors using phthalocyanine photodynamic therapy. Barr, H., Tralau, C.J., Boulos, P.B., MacRobert, A.J., Krasner, N., Phillips, D., Bown, S.G. Gastroenterology (1990) [Pubmed]
  33. Monoclonal antibodies to a rat colon carcinoma: model for monoclonal antibody therapy of solid tumors. Douillard, J.Y., Laborda, J., Burg, C., Ridge, J., Levenbook, I., Blottière, H., Sela, B., Hoffman, T., Ben Ami, S. Cancer Res. (1989) [Pubmed]
  34. Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently. Park, H.S., Goodlad, R.A., Ahnen, D.J., Winnett, A., Sasieni, P., Lee, C.Y., Wright, N.A. Am. J. Pathol. (1997) [Pubmed]
  35. Induction of renal tumours in rats by the administration of 1,2 dimethylhydrazine. Sunter, J.P., Senior, P.V. J. Pathol. (1983) [Pubmed]
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