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Chemical Compound Review

Dimethylnitrosamine     N,N-dimethylnitrous amide

Synonyms: DMNA, CCRIS 261, CHEMBL117311, AG-G-31082, CHEBI:35807, ...
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Disease relevance of Dimethylnitrosamine


Psychiatry related information on Dimethylnitrosamine


High impact information on Dimethylnitrosamine


Chemical compound and disease context of Dimethylnitrosamine


Biological context of Dimethylnitrosamine


Anatomical context of Dimethylnitrosamine


Associations of Dimethylnitrosamine with other chemical compounds


Gene context of Dimethylnitrosamine


Analytical, diagnostic and therapeutic context of Dimethylnitrosamine


  1. SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. Yoshida, T., Ogata, H., Kamio, M., Joo, A., Shiraishi, H., Tokunaga, Y., Sata, M., Nagai, H., Yoshimura, A. J. Exp. Med. (2004) [Pubmed]
  2. Morphologic character of transforming renal cell cultures derived from Wistar rats given dimethylnitrosamine. Hard, G.C., Borland, R. J. Natl. Cancer Inst. (1977) [Pubmed]
  3. Carcinogenicity and acute toxicity of dimethylnitrosamine in rainbow trout (Salmo gairdneri). Grieco, M.P., Hendricks, J.D., Scanlan, R.A., Sinnhuber, R.O., Pierce, D.A. J. Natl. Cancer Inst. (1978) [Pubmed]
  4. Kupffer cell sarcoma in rats after exposure to small doses of dimethylnitrosamine and N-2-acetylaminofluorene during hepatic regeneration. Chopra, P., Manga, A., Nayak, N.C. J. Natl. Cancer Inst. (1979) [Pubmed]
  5. Induction of changes in the pepsinogen content and the pepsinogen isoenzyme pattern of the pyloric mucosa of the rat stomach by short-term administration of stomach carcinogens. Furihata, C., Kodama, K., Matsushima, T. J. Natl. Cancer Inst. (1981) [Pubmed]
  6. Intake of volatile nitrosamines from consumption of alcohols. Walker, E.A., Castegnaro, M., Garren, L., Toussaint, G., Kowalski, B. J. Natl. Cancer Inst. (1979) [Pubmed]
  7. Role of ethanol-inducible cytochrome P-450 2E1 in the development of hepatocellular carcinoma by the chemical carcinogen, N-nitrosodimethylamine. Tsutsumi, M., Matsuda, Y., Takada, A. Hepatology (1993) [Pubmed]
  8. Dietary modifications affecting the mutagenicity of N-nitroso compounds in the host-mediated assay. Zeiger, E. Cancer Res. (1975) [Pubmed]
  9. Effects of N-nitrosodimethylamine on tumor susceptibility. Duke, S.S., Schook, L.B., Holsapple, M.P. J. Leukoc. Biol. (1985) [Pubmed]
  10. Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats. Aitio, A., Aitio, M.L., Camus, A.M., Cardis, E., Bartsch, H. Jpn. J. Cancer Res. (1991) [Pubmed]
  11. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Harvey, M., McArthur, M.J., Montgomery, C.A., Butel, J.S., Bradley, A., Donehower, L.A. Nat. Genet. (1993) [Pubmed]
  12. Generation of dimethylnitrosamine in water purification systems. Detection in human blood samples during hemodialysis. Simenhoff, M.L., Dunn, S.R., Fiddler, W., Pensabene, J.W., Smiley, J. JAMA (1983) [Pubmed]
  13. von Hippel-Lindau gene mutations in N-nitrosodimethylamine-induced rat renal epithelial tumors. Shiao, Y.H., Rice, J.M., Anderson, L.M., Diwan, B.A., Hard, G.C. J. Natl. Cancer Inst. (1998) [Pubmed]
  14. N-nitrosodimethylamine blood levels in patients with chronic renal failure: modulation of levels by ethanol and ascorbic acid. Dunn, S.R., Simenhoff, M.L., Lele, P.S., Goyal, S., Pensabene, J.W., Fiddler, W. J. Natl. Cancer Inst. (1990) [Pubmed]
  15. A method for the amplification of chemically induced transformation in C3H/10T1/2 clone 8 cells: its use as a potential screening assay. Schechtman, L.M., Kiss, E., McCarvill, J., Nims, R., Kouri, R.E., Lubet, R.A. J. Natl. Cancer Inst. (1987) [Pubmed]
  16. Pathogenesis of dimethylnitrosamine-induced hepatocellular cancer in hamster liver and lack of enhancement by phenobarbital. Stenbäck, F., Mori, H., Furuya, K., Williams, G.M. J. Natl. Cancer Inst. (1986) [Pubmed]
  17. Selective induction of intestinal tumors in rats by methyl(acetoxymethyl)nitrosamine, an ester of the presumed reactive metabolite of dimethylnitrosamine. Joshi, S.R., Rice, J.M., Wenk, M.L., Roller, P.P., Keefer, L.K. J. Natl. Cancer Inst. (1977) [Pubmed]
  18. Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole. Vermeer, I.T., Engels, L.G., Pachen, D.M., Dallinga, J.W., Kleinjans, J.C., van Maanen, J.M. Gastroenterology (2001) [Pubmed]
  19. Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker. Skopek, T.R., Liber, H.L., Krolewski, J.J., Thilly, W.G. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  20. High levels of acetaldehyde in nonalcoholic liver injury after threonine or ethanol administration. Ma, X.L., Baraona, E., Hernández-Muñoz, R., Lieber, C.S. Hepatology (1989) [Pubmed]
  21. DNA alkylation and tumor induction in regenerating rat liver after cell cycle-related continuous N-nitrosodimethylamine infusion. Rabes, H.M., Kerler, R., Wilhelm, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  22. Effect of protein diet on age-dependent methylation of liver nuclear components of mice administered N-nitrosodimethylamine. Klaude, M., von der Decken, A. J. Natl. Cancer Inst. (1984) [Pubmed]
  23. Kinetic studies on the hepatic microsomal metabolism of dimethylnitrosamine, diethylnitrosamine, and methylethylnitrosamine in the rat. Chau, I.Y., Dagani, D., Archer, M.C. J. Natl. Cancer Inst. (1978) [Pubmed]
  24. Nephroblastoma in the rat: histology of a spontaneous tumor, identity with respect to renal mesenchymal neoplasms, and a review of previously recorded cases. Hard, G.C., Grasso, P. J. Natl. Cancer Inst. (1976) [Pubmed]
  25. Dimethylnitrosamine demethylase activity in fetal, suckling, and maternal mouse liver and its transplacental and transmammary induction by polychlorinated biphenyls. Jannetti, R.A., Anderson, L.M. J. Natl. Cancer Inst. (1981) [Pubmed]
  26. Inhibition of dimethylnitrosamine-induced strand breaks in liver DNA and liver cell necrosis by diethyldithiocarbamate. Abanobi, S.E., Popp, J.A., Chang, S.K., Harrington, G.W., Lotlikar, P.D., Hadjiolov, D., Levitt, M., Rajalakshmi, S., Sarma, D.S. J. Natl. Cancer Inst. (1977) [Pubmed]
  27. Effects of oxygen depletion on in vitro metabolism of dimethylnitrosamine in microsomes from rat liver and human tissues. Lin, H.J., Fong, L.Y. J. Natl. Cancer Inst. (1980) [Pubmed]
  28. Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine. Dagani, D., Archer, M.C. J. Natl. Cancer Inst. (1976) [Pubmed]
  29. Correlation between balance of specific chromosomes and expression of malignancy in hamster cells. Benedict, W.F., Rucker, N., Mark, C., Kouri, R.E. J. Natl. Cancer Inst. (1975) [Pubmed]
  30. Inhibition of the NA(+)/H(+) exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study. Benedetti, A., Di Sario, A., Casini, A., Ridolfi, F., Bendia, E., Pigini, P., Tonnini, C., D'Ambrosio, L., Feliciangeli, G., Macarri, G., Svegliati-Baroni, G. Gastroenterology (2001) [Pubmed]
  31. Administration of N-nitrosodimethylamine, N-nitrosopyrrolidine, or N'-nitrosonornicotine to nursing rats: their interactions with liver and kidney nucleic acids from sucklings. Díaz Gómez, M.I., Tamayo, D., Castro, J.A. J. Natl. Cancer Inst. (1986) [Pubmed]
  32. Carcinogen-induced DNA damage and cellular alterations in F344 rat colon organ cultures. Telang, N.T., Williams, G.M. J. Natl. Cancer Inst. (1982) [Pubmed]
  33. alpha-Hydroxylation pathway in the in vitro metabolism of carcinogenic nitrosamines: N-nitrosodimethylamine and N-nitroso-N-methylaniline. Kroeger-Koepke, M.B., Koepke, S.R., McClusky, G.A., Magee, P.N., Michejda, C.J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  34. Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts. Margison, G.P., Pegg, A.E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  35. Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. Zanesi, N., Mancini, R., Sevignani, C., Vecchione, A., Kaou, M., Valtieri, M., Calin, G.A., Pekarsky, Y., Gnarra, J.R., Croce, C.M., Huebner, K. Cancer Res. (2005) [Pubmed]
  36. Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Bellec, G., Dréano, Y., Lozach, P., Ménez, J.F., Berthou, F. Carcinogenesis (1996) [Pubmed]
  37. CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. Godoy, W., Albano, R.M., Moraes, E.G., Pinho, P.R., Nunes, R.A., Saito, E.H., Higa, C., Filho, I.M., Kruel, C.D., Schirmer, C.C., Gurski, R., Lang, M.A., Pinto, L.F. Carcinogenesis (2002) [Pubmed]
  38. Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis. Svegliati-Baroni, G., Ridolfi, F., Caradonna, Z., Alvaro, D., Marzioni, M., Saccomanno, S., Candelaresi, C., Trozzi, L., Macarri, G., Benedetti, A., Folli, F. J. Hepatol. (2003) [Pubmed]
  39. Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine. Pollard, M., Luckert, P.H. Science (1981) [Pubmed]
  40. Production of kidney tumors in rats with low dose of dimethylnitrosamine after partial hepatectomy. Evarts, R.P., Brown, C.A., Mostafa, M.H. J. Natl. Cancer Inst. (1982) [Pubmed]
  41. Distinctive patterns of proliferative activity in kidney cell cultures derived from normal dimethylnitrosamine-treated, and renal tumor-bearing rats. Stewart, B.W., Hard, G.C. J. Natl. Cancer Inst. (1977) [Pubmed]
  42. Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens. Langenbach, R., Freed, H.J., Huberman, E. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  43. Mechanistic and statistical insight into the large carcinogenesis bioassays on N-nitrosodiethylamine and N-nitrosodimethylamine. Swenberg, J.A., Hoel, D.G., Magee, P.N. Cancer Res. (1991) [Pubmed]
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