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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Midline pineal tumors and suprasellar germinomas: highly curable by irradiation.

Sixty-one patients with midline pineal tumors and 16 patients with suprasellar germinomas were treated with surgical decompression and relatively high-dose radiotherapy of the primary site. Results were excellent, and there were no long-term complications. Ten per cent of midline pineal tumors and 37% of suprasellar germinomas metastasized to the cerebral or spinal subarachnoid space within 6 months to 5 years. Irradiation of the entire neural axis is recommended for locally extensive tumors, simultaneous pineal and hypothalamic lesions, and all biopsy-proved germinomas. The five-year survival rate was 79% for midline pineal tumors and 77% for suprasellar germinomas.[1]


  1. Midline pineal tumors and suprasellar germinomas: highly curable by irradiation. Sung, D.I., Harisliadis, L., Chang, C.H. Radiology. (1978) [Pubmed]
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