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MeSH Review


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Disease relevance of Germinoma


High impact information on Germinoma

  • Seven of nine (78%) patients with germinoma survived disease-free after HDC with a median survival of 48 months [6].
  • Etoposide and cisplatin (EP) were used for the treatment of solitary pure germinomas, and ifosfamide, cisplatin, and etoposide (ICE) were used for the treatment of other GCTs [1].
  • These data suggested that INK4a/ARF gene abnormalities could play an important role in the genesis of ICGTs, especially in pure germinoma [7].
  • PATIENTS AND METHODS: Eight patients with CNS germinoma received carboplatin, etoposide, and bleomycin as their only nonsurgical treatment following their initial diagnosis [8].
  • In one germinoma, low amounts of somatostatin receptors were observed over the lymphocytic elements [9].

Chemical compound and disease context of Germinoma

  • A suprasellar germinoma, initially thought to be granulomatous diencephalitis of uncertain cause, responded following chloramphenicol and methicillin treatment both by clinical and radiographic criteria and was not diagnosed until a third biopsy was performed [10].
  • This study analyzes secretion of melatonin and pituitary hormones in 14 patients with germinoma originating in the pineal or the hypothalamic-neurohypophyseal region [11].
  • METHODS AND MATERIALS: Following etoposide and cisplatin with or without ifosfamide, 13 patients with nondisseminated disease received involved-field irradiation of 24 Gy in 12 fractions within 3 weeks and 2 patients with disseminated germinoma received 24 Gy craniospinal irradiation (CSI) [12].
  • Angiotensin-I-converting enzyme in germinomas [13].
  • Angiotensin I-converting enzyme in a suprasellar germinoma [14].

Biological context of Germinoma


Anatomical context of Germinoma


Gene context of Germinoma


Analytical, diagnostic and therapeutic context of Germinoma


  1. Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors. Aoyama, H., Shirato, H., Ikeda, J., Fujieda, K., Miyasaka, K., Sawamura, Y. J. Clin. Oncol. (2002) [Pubmed]
  2. The fine structure of thymoma, with emphasis on its differential diagnosis. A study of ten cases. Levine, G.D., Rosai, J., Bearman, R.M., Polliack, A. Am. J. Pathol. (1975) [Pubmed]
  3. Aromatase expression in human germinomas with possible biological effects. O'Marcaigh, A.S., Ledger, G.A., Roche, P.C., Parisi, J.E., Zimmerman, D. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  4. Neuroendocrine, immunohistochemical, and ultrastructural study of pineal region tumors. Grimoldi, N., Tomei, G., Stankov, B., Lucini, V., Masini, B., Caputo, V., Repetti, M.L., Lazzarini, G., Gaini, S.M., Lucarini, C., Fraschini, F., Villani, R. J. Pineal Res. (1998) [Pubmed]
  5. Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Ulbright, T.M. Mod. Pathol. (2005) [Pubmed]
  6. Thiotepa-based high-dose chemotherapy with autologous stem-cell rescue in patients with recurrent or progressive CNS germ cell tumors. Modak, S., Gardner, S., Dunkel, I.J., Balmaceda, C., Rosenblum, M.K., Miller, D.C., Halpern, S., Finlay, J.L. J. Clin. Oncol. (2004) [Pubmed]
  7. Alterations of the INK4a/ARF locus in human intracranial germ cell tumors. Iwato, M., Tachibana, O., Tohma, Y., Arakawa, Y., Nitta, H., Hasegawa, M., Yamashita, J., Hayashi, Y. Cancer Res. (2000) [Pubmed]
  8. Radiation therapy for relapsed CNS germinoma after primary chemotherapy. Merchant, T.E., Davis, B.J., Sheldon, J.M., Leibel, S.A. J. Clin. Oncol. (1998) [Pubmed]
  9. Distribution and biochemical characterization of somatostatin receptors in tumors of the human central nervous system. Reubi, J.C., Lang, W., Maurer, R., Koper, J.W., Lamberts, S.W. Cancer Res. (1987) [Pubmed]
  10. Suprasellar germinoma. Unresolved problems in diagnosis, pathogenesis, and management. Kasper, C.S., Schneider, N.R., Childers, J.H., Wilson, J.D. Am. J. Med. (1983) [Pubmed]
  11. Twenty-four hour rhythm of melatonin in patients with a history of pineal and/or hypothalamo-neurohypophyseal germinoma. Murata, J., Sawamura, Y., Ikeda, J., Hashimoto, S., Honma, K. J. Pineal Res. (1998) [Pubmed]
  12. Preirradiation evaluation and technical assessment of involved-field radiotherapy using computed tomographic (CT) simulation and neoadjuvant chemotherapy for intracranial germinoma. Kitamura, K., Shirato, H., Sawamura, Y., Suzuki, K., Ikeda, J., Miyasaka, K. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  13. Angiotensin-I-converting enzyme in germinomas. Saint-Andre, J.P., Alhenc-Gelas, F., Rohmer, V., Chretien, M.F., Bigorgne, J.C., Corvol, P. Hum. Pathol. (1988) [Pubmed]
  14. Angiotensin I-converting enzyme in a suprasellar germinoma. Rohmer, V., Saint-Andre, J.P., Alhenc-Gelas, F., Corvol, P., Bigorgne, J.C. Am. J. Clin. Pathol. (1987) [Pubmed]
  15. C-kit gene mutation: common and widely distributed in intracranial germinomas. Kamakura, Y., Hasegawa, M., Minamoto, T., Yamashita, J., Fujisawa, H. J. Neurosurg. (2006) [Pubmed]
  16. Radiotherapy for tumours of the pineal region and suprasellar germinomas. Glanzmann, C., Seelentag, W. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1989) [Pubmed]
  17. Occurrence of GH deficiency in adult patients who underwent neurosurgery in the hypothalamus-pituitary area for non-functioning tumour masses. Corneli, G., Baldelli, R., Di Somma, C., Rovere, S., Gaia, D., Pellegrino, M., Gasco, V., Durante, C., Grottoli, S., Colao, A., Tamburrano, G., Lombardi, G., Ghigo, E., Aimaretti, G. Growth Horm. IGF Res. (2003) [Pubmed]
  18. A comparative study of apoptosis and proliferation in germinoma and glioblastoma. Mizoguchi, M., Inamura, T., Shono, T., Ikezaki, K., Inoha, S., Ohgami, S., Fukui, M. Neuro-oncology (2000) [Pubmed]
  19. Pineal germinoma with syncytiotrophoblastic giant cells: a case with panhypopituitarism and isosexual pseudopuberty. Laidler, P., Pounder, D.J. Hum. Pathol. (1984) [Pubmed]
  20. Pathobiology of intracranial germ-cell tumors: immunochemical, immunohistochemical, and electron microscopic investigations. Inoue, H.K., Naganuma, H., Ono, N. J. Neurooncol. (1987) [Pubmed]
  21. Lack of plasma prolactin response to intravenously injected vasoactive intestinal polypeptide in patients with prolactin-secreting adenoma. Kaji, H., Chihara, K., Kita, T., Kashio, Y., Okimura, Y., Fujita, T. Acta Endocrinol. (1985) [Pubmed]
  22. Immunohistochemical and in vitro functional analysis of pineal-germinoma infiltrating lymphocytes: report of a case. Sawamura, Y., Hamou, M.F., Kuppner, M.C., de Tribolet, N. Neurosurgery (1989) [Pubmed]
  23. c-kit gene mutations in intracranial germinomas. Sakuma, Y., Sakurai, S., Oguni, S., Satoh, M., Hironaka, M., Saito, K. Cancer Sci. (2004) [Pubmed]
  24. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Hattab, E.M., Tu, P.H., Wilson, J.D., Cheng, L. Am. J. Surg. Pathol. (2005) [Pubmed]
  25. Mediastinal growing teratoma syndrome after cisplatin-based chemotherapy and radiotherapy for intracranial germinoma. Iwata, H., Mori, Y., Takagi, H., Shirahashi, K., Shinoda, J., Shimokawa, K., Hirose, H. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
  26. Late recurrence of pineal germinoma. Wenger, M., Lövblad, K.O., Markwalder, R., Taub, E. Surgical neurology. (2002) [Pubmed]
  27. Usefulness of gallium-67 scintigraphy in neurohypophyseal germinoma. Abe, T., Tanioka, D., Izumiyama, H., Matsumoto, K., Shinozuka, A. Acta neurochirurgica. (2000) [Pubmed]
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