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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.

The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.[1]


  1. L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis. Fozard, J.R., Part, M.L., Prakash, N.J., Grove, J., Schechter, P.J., Sjoerdsma, A., Koch-Weser, J. Science (1980) [Pubmed]
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