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Chemical Compound Review

ornithine     2,5-diaminopentanoic acid

Synonyms: DL-Ornithine, Ornithine, DL-, AGN-PC-00PNS9, AG-G-24674, ALBB-005910, ...
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Disease relevance of ornithine


Psychiatry related information on ornithine


High impact information on ornithine


Chemical compound and disease context of ornithine


Biological context of ornithine


Anatomical context of ornithine


Associations of ornithine with other chemical compounds

  • Two-thirds of L-arginine consumption was due to macrophage arginase yielding L-ornithine and urea, which accumulated in medium [26].
  • Arginase converts L-arginine to L-ornithine, which is the precursor of polyamines, which are essential components of cell proliferation [27].
  • Treatment of SMC with PDGF stimulated DNA and putrescine synthesis, and this was enhanced further by increasing the extracellular concentration of L-ornithine [28].
  • Two forms of ornithine decarboxylase (L-ornithine carboxy-lyase, EC were purified from the livers of rats which had been treated with thioacetamide for 16 h (for details, see miniprint to Obenrader, M.F., and Prouty, W. F. (1977) J. Biol. Chem. 252, 2860-2865) [29].
  • The P4XB2 strain, which is an arg R regulatory mutant, has a reduced lag effect in the presence of the tripeptide and appears to react to the intoxication by a further adjustment of the L-ornithine carbamoyltransferase cellular level [30].

Gene context of ornithine


Analytical, diagnostic and therapeutic context of ornithine


  1. Gyrate atrophy of the retina: inborn error of L-ornithin:2-oxoacid aminotransferase. O'Donnell, J.J., Sandman, R.P., Martin, S.R. Science (1978) [Pubmed]
  2. Modulation of ornithine decarboxylase activity in Escherichia coli by positive and negative effectors. Kyriakidis, D.A., Heller, J.S., Canellakis, E.S. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  3. Ornithine decarboxylase from mouse epidermis and epidermal papillomas: differences in enzymatic properties and structure. O'Brien, T.G., Madara, T., Pyle, J.A., Holmes, M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Induction of a protein inhibitor to ornithine decarboxylase by the end products of its reaction. Heller, J.S., Fong, W.F., Canellakis, E.S. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  5. Acute hypoxia increases ornithine decarboxylase activity and polyamine concentrations in fetal rat brain. Longo, L.D., Packianathan, S., McQueary, J.A., Stagg, R.B., Byus, C.V., Cain, C.D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis. Fozard, J.R., Part, M.L., Prakash, N.J., Grove, J., Schechter, P.J., Sjoerdsma, A., Koch-Weser, J. Science (1980) [Pubmed]
  7. Increased immunostaining for L-ornithine decarboxylase occurs in neocortical neurons of Alzheimer's disease patients. Bernstein, H.G., Müller, M. Neurosci. Lett. (1995) [Pubmed]
  8. Clinical, biochemical and ultrastructural study on the pathogenesis of hyperornithinemia-hyperammonemia-homocitrullinuria syndrome. Nakajima, M., Ishii, S., Mito, T., Takeshita, K., Takashima, S., Takakura, H., Inoue, I., Saheki, T., Akiyoshi, H., Ichihara, K. Brain Dev. (1988) [Pubmed]
  9. The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages. Iniesta, V., Gómez-Nieto, L.C., Corraliza, I. J. Exp. Med. (2001) [Pubmed]
  10. Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis. Humm, A., Fritsche, E., Steinbacher, S., Huber, R. EMBO J. (1997) [Pubmed]
  11. Transcriptional effects of polyamines on ribosomal proteins and on polyamine-synthesizing enzymes in Escherichia coli. Huang, S.C., Panagiotidis, C.A., Canellakis, E.S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  12. Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities. Insel, P.A., Fenno, J. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  13. Nonstereospecific transamination catalyzed by pyridoxal phosphate-dependent amino acid racemases of broad substrate specificity. Lim, Y.H., Yoshimura, T., Kurokawa, Y., Esaki, N., Soda, K. J. Biol. Chem. (1998) [Pubmed]
  14. Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin. Rosowsky, A., Bader, H., Wright, J.E., Keyomarsi, K., Matherly, L.H. J. Med. Chem. (1994) [Pubmed]
  15. Experimental model of gyrate atrophy in animals. Kuwabara, T., Ishikawa, Y., Kaiser-Kupfer, M.I. Ophthalmology (1981) [Pubmed]
  16. Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture. Mamont, P.S., Böhlen, P., McCann, P.P., Bey, P., Schuber, F., Tardif, C. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  17. sid1, a gene initiating siderophore biosynthesis in Ustilago maydis: molecular characterization, regulation by iron, and role in phytopathogenicity. Mei, B., Budde, A.D., Leong, S.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  18. Phosphorylation of ornithine decarboxylase by a polyamine-dependent protein kinase. Atmar, V.J., Kuehn, G.D. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. Inhibition of induced L-ornithine decarboxylase stimulation and erythrodifferentiation in Friend erythroleukemia cells by 2',5'-isoadenylate trimer core. Gazitt, Y. Cancer Res. (1981) [Pubmed]
  20. Human ornithine transcarbamylase. Purification and characterization of the enzyme from normal liver and the liver of a Reye's syndrome patient. Pierson, D.L., Cox, S.L., Gilbert, B.E. J. Biol. Chem. (1977) [Pubmed]
  21. At least two mutant alleles of ornithine delta-aminotransferase cause gyrate atrophy of the choroid and retina in Finns. Mitchell, G.A., Brody, L.C., Sipila, I., Looney, J.E., Wong, C., Engelhardt, J.F., Patel, A.S., Steel, G., Obie, C., Kaiser-Kupfer, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  22. Mouse ornithine decarboxylase gene: cloning, structure, and expression. Brabant, M., McConlogue, L., van Daalen Wetters, T., Coffino, P. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  23. Synthesis, intracellular transport, and processing of the precursors for mitochondrial ornithine transcarbamylase and carbamoyl-phosphate synthetase I in isolated hepatocytes. Mori, M., Morita, T., Ikeda, F., Amaya, Y., Tatibana, M., Cohen, P.P. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  24. Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats. MacDonnell, P.C., Nagaiah, K., Lakshmanan, J., Guroff, G. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  25. The cellular localization of the L-ornithine decarboxylase/polyamine system in normal and diseased central nervous systems. Bernstein, H.G., Müller, M. Prog. Neurobiol. (1999) [Pubmed]
  26. Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. Granger, D.L., Hibbs, J.B., Perfect, J.R., Durack, D.T. J. Clin. Invest. (1990) [Pubmed]
  27. Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. Singh, R., Pervin, S., Karimi, A., Cederbaum, S., Chaudhuri, G. Cancer Res. (2000) [Pubmed]
  28. Platelet-derived growth factor regulates vascular smooth muscle cell proliferation by inducing cationic amino acid transporter gene expression. Durante, W., Liao, L., Iftikhar, I., Cheng, K., Schafer, A.I. J. Biol. Chem. (1996) [Pubmed]
  29. Production of monospecific antibodies to rat liver ornithine decarboxylase and their use in turnover studies. Obenrader, M.F., Prouty, W.F. J. Biol. Chem. (1977) [Pubmed]
  30. Synthesis of a peptide form of N-delta-(phosphonoacetyl)-L-ornithine. Its antibacterial effect through the specific inhibition of Escherichia coli L-ornithine carbamoyltransferase. Penninckx, M., Gigot, D. J. Biol. Chem. (1979) [Pubmed]
  31. Helicobacter pylori induces macrophage apoptosis by activation of arginase II. Gobert, A.P., Cheng, Y., Wang, J.Y., Boucher, J.L., Iyer, R.K., Cederbaum, S.D., Casero, R.A., Newton, J.C., Wilson, K.T. J. Immunol. (2002) [Pubmed]
  32. Arginase I induction during Leishmania major infection mediates the development of disease. Iniesta, V., Carcelén, J., Molano, I., Peixoto, P.M., Redondo, E., Parra, P., Mangas, M., Monroy, I., Campo, M.L., Nieto, C.G., Corraliza, I. Infect. Immun. (2005) [Pubmed]
  33. Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II. Levillain, O., Hus-Citharel, A., Garvi, S., Peyrol, S., Reymond, I., Mutin, M., Morel, F. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  34. Synergistic interaction of interleukin-1 beta and growth factors in primary cultures of rat aortic smooth muscle cells. Bourcier, T., Dockter, M., Hassid, A. J. Cell. Physiol. (1995) [Pubmed]
  35. Interaction between arginase and L-ornithine carbamoyltransferase in Saccharomyces cerevisiae. The regulatory sites of arginase. Penninckx, M. Eur. J. Biochem. (1975) [Pubmed]
  36. High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase. Craig, S.P., Yuan, L., Kuntz, D.A., McKerrow, J.H., Wang, C.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  37. Chiral separation based on ligand-exchange capillary electrophoresis using a copper(II)-L-ornithine ternary complex as selector. Zheng, Z.X., Wei, Y., Lin, J.M. Electrophoresis (2005) [Pubmed]
  38. A comparison of ornithine decarboxylases from normal and SV40-transformed 3T3 mouse fibroblasts. Weiss, J.M., Lembach, K.J., Boucek, R.J. Biochem. J. (1981) [Pubmed]
  39. Ornithine decarboxylase and S-adenosylmethionine decarboxylase activity in the accessory sex organs of intact, castrated, and androgen-stimulated castrated rats. Fjösne, H.E., Strand, H., Ostensen, M.A., Sunde, A. Prostate (1988) [Pubmed]
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