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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Induction of tumors of the forestomach in rats by oral application of N-methyl-N'-nitro-nitrosoguanidine.

After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell carcinomas with infiltrative growth in 88/98 (89%) animals. Tumorigenic lesions in the glandular stomach ware only observed in 3/98 rats. In two of these animals, mucosal adenocarcinomas were found and in the third a leiomyosarcoma. In about 30% of the animals treated with MNNG, degenerative liver changes were found, especially single cell and focal necroses, cystic alterations, and bile-duct proliferations.[1]

References

  1. Induction of tumors of the forestomach in rats by oral application of N-methyl-N'-nitro-nitrosoguanidine. Eichler, G., Habs, M., Schmähl, D. J. Cancer Res. Clin. Oncol. (1983) [Pubmed]
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