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Disease relevance of Leiomyosarcoma


High impact information on Leiomyosarcoma

  • Case 3-1981: leiomyosarcoma of inferior vena cava [6].
  • In assays of anchorage-independent growth and in vivo tumorigenicity, both growth and tumorigenicity were statistically significantly reduced in calponin h1-transfected leiomyosarcoma cells [7].
  • Clinically, transfer of a calponin h1 complementary DNA into poorly differentiated leiomyosarcoma cells may be of potential therapeutic value through induction of a normal, differentiated cellular phenotype [7].
  • We report on the use of 1H-NMR two-dimensional total correlated spectroscopy (2D TOCSY) at 600 MHz for an ex vivo analysis of fatty acyl chain lipid in normal smooth muscle and a series of primary retroperitoneal leiomyosarcomas [8].
  • 1H-NMR detectable fatty acyl chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity [8].

Chemical compound and disease context of Leiomyosarcoma


Biological context of Leiomyosarcoma


Anatomical context of Leiomyosarcoma


Gene context of Leiomyosarcoma


Analytical, diagnostic and therapeutic context of Leiomyosarcoma


  1. Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS. McClain, K.L., Leach, C.T., Jenson, H.B., Joshi, V.V., Pollock, B.H., Parmley, R.T., DiCarlo, F.J., Chadwick, E.G., Murphy, S.B. N. Engl. J. Med. (1995) [Pubmed]
  2. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. Carney, J.A., Sheps, S.G., Go, V.L., Gordon, H. N. Engl. J. Med. (1977) [Pubmed]
  3. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. Daughaday, W.H., Emanuele, M.A., Brooks, M.H., Barbato, A.L., Kapadia, M., Rotwein, P. N. Engl. J. Med. (1988) [Pubmed]
  4. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Kim, K.J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H.S., Ferrara, N. Nature (1993) [Pubmed]
  5. MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. Flørenes, V.A., Maelandsmo, G.M., Forus, A., Andreassen, A., Myklebost, O., Fodstad, O. J. Natl. Cancer Inst. (1994) [Pubmed]
  6. Case 3-1981: leiomyosarcoma of inferior vena cava. Cantwell, B. N. Engl. J. Med. (1981) [Pubmed]
  7. Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma. Horiuchi, A., Nikaido, T., Taniguchi, S., Fujii, S. J. Natl. Cancer Inst. (1999) [Pubmed]
  8. 1H-NMR detectable fatty acyl chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity. Singer, S., Sivaraja, M., Souza, K., Millis, K., Corson, J.M. J. Clin. Invest. (1996) [Pubmed]
  9. Effect of flurbiprofen and 16,16-dimethyl-prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. I. Squamous epithelium and mesenchymal tissue. Lehnert, T., Deschner, E.E., Karmali, R.A., DeCosse, J.J. J. Natl. Cancer Inst. (1987) [Pubmed]
  10. Leiomyomas and leiomyosarcomas of the kidney in 4-day-old BUF rats given methylazoxymethanol acetate intraperitoneally. Reuber, M.D. J. Natl. Cancer Inst. (1976) [Pubmed]
  11. Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial. Hensley, M.L., Maki, R., Venkatraman, E., Geller, G., Lovegren, M., Aghajanian, C., Sabbatini, P., Tong, W., Barakat, R., Spriggs, D.R. J. Clin. Oncol. (2002) [Pubmed]
  12. Leiomyosarcoma of the urinary bladder after cyclophosphamide. Pedersen-Bjergaard, J., Jønsson, V., Pedersen, M., Hou-Jensen, K. J. Clin. Oncol. (1995) [Pubmed]
  13. Phase II trial of cisplatin as first-line chemotherapy in patients with advanced or recurrent uterine sarcomas: a Gynecologic Oncology Group study. Thigpen, J.T., Blessing, J.A., Beecham, J., Homesley, H., Yordan, E. J. Clin. Oncol. (1991) [Pubmed]
  14. Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. Lehtonen, R., Kiuru, M., Vanharanta, S., Sjöberg, J., Aaltonen, L.M., Aittomäki, K., Arola, J., Butzow, R., Eng, C., Husgafvel-Pursiainen, K., Isola, J., Järvinen, H., Koivisto, P., Mecklin, J.P., Peltomäki, P., Salovaara, R., Wasenius, V.M., Karhu, A., Launonen, V., Nupponen, N.N., Aaltonen, L.A. Am. J. Pathol. (2004) [Pubmed]
  15. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. Cao, X., Cismowski, M.J., Sato, M., Blumer, J.B., Lanier, S.M. J. Biol. Chem. (2004) [Pubmed]
  16. EMILIN, a component of the elastic fiber and a new member of the C1q/tumor necrosis factor superfamily of proteins. Doliana, R., Mongiat, M., Bucciotti, F., Giacomello, E., Deutzmann, R., Volpin, D., Bressan, G.M., Colombatti, A. J. Biol. Chem. (1999) [Pubmed]
  17. Molecular cloning of TA16, a transcriptional repressor that may mediate glucocorticoid-induced growth arrest of leiomyosarcoma cells. Fan, W., Ma, J.X., Cheng, L., Norris, J.S. Mol. Endocrinol. (1997) [Pubmed]
  18. In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Sciacca, L., Mineo, R., Pandini, G., Murabito, A., Vigneri, R., Belfiore, A. Oncogene (2002) [Pubmed]
  19. Insulin-like growth factor gene expression in human smooth muscle tumors. Gloudemans, T., Prinsen, I., Van Unnik, J.A., Lips, C.J., Den Otter, W., Sussenbach, J.S. Cancer Res. (1990) [Pubmed]
  20. Left atrial leiomyosarcoma: manifestation as unexplained pulmonary vascular disease. Donovan, V.M., Summer, W., Hutchins, G.M. Arch. Intern. Med. (1982) [Pubmed]
  21. Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas. Hudson, C.E., Schulte, B.A., Sutter, T.R., Norris, J.S. Carcinogenesis (2001) [Pubmed]
  22. A phase II clinical trial of diaziquone (AZQ) in the treatment of patients with recurrent leiomyosarcoma of the uterus. A Gynecologic Oncology Group study. Slayton, R.E., Blessing, J.A., Look, K., Anderson, B. Investigational new drugs. (1991) [Pubmed]
  23. Cervical paravertebral leiomyosarcoma mimicking a nerve sheath tumor. SenGupta, S.K., Nag, S. Hum. Pathol. (1992) [Pubmed]
  24. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Zhang, L., Yu, D., Hu, M., Xiong, S., Lang, A., Ellis, L.M., Pollock, R.E. Cancer Res. (2000) [Pubmed]
  25. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Aström, A.K., Voz, M.L., Kas, K., Röijer, E., Wedell, B., Mandahl, N., Van de Ven, W., Mark, J., Stenman, G. Cancer Res. (1999) [Pubmed]
  26. Involvement of cyclins in cell proliferation and their clinical implications in soft tissue smooth muscle tumors. Noguchi, T., Dobashi, Y., Minehara, H., Itoman, M., Kameya, T. Am. J. Pathol. (2000) [Pubmed]
  27. NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. Ueda, A., Okuda, K., Ohno, S., Shirai, A., Igarashi, T., Matsunaga, K., Fukushima, J., Kawamoto, S., Ishigatsubo, Y., Okubo, T. J. Immunol. (1994) [Pubmed]
  28. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Hernando, E., Charytonowicz, E., Dudas, M.E., Menendez, S., Matushansky, I., Mills, J., Socci, N.D., Behrendt, N., Ma, L., Maki, R.G., Pandolfi, P.P., Cordon-Cardo, C. Nat. Med. (2007) [Pubmed]
  29. Prognostic significance of macrophage infiltration in leiomyosarcomas. Lee, C.H., Espinosa, I., Vrijaldenhoven, S., Subramanian, S., Montgomery, K.D., Zhu, S., Marinelli, R.J., Peterse, J.L., Poulin, N., Nielsen, T.O., West, R.B., Gilks, C.B., van de Rijn, M. Clin. Cancer Res. (2008) [Pubmed]
  30. Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. Swanson, P.E., Manivel, J.C., Wick, M.R. Am. J. Pathol. (1987) [Pubmed]
  31. p53 immunoreactivity and mutation of the p53 gene in smooth muscle tumours of the uterine corpus. Jeffers, M.D., Farquharson, M.A., Richmond, J.A., McNicol, A.M. J. Pathol. (1995) [Pubmed]
  32. Expressions of basic fibroblast growth factor and fibroblast growth factor receptor mRNA in soft tissue tumors by in situ hybridization. Tamiya, S., Ueki, T., Tsuneyoshi, M. Mod. Pathol. (1998) [Pubmed]
  33. Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. Häffner, A.C., Zepter, K., Fritz, T., Dummer, R., Lejeune, F.J., Burg, G. Br. J. Dermatol. (1999) [Pubmed]
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