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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Disposition kinetics of metronidazole in children.

The pharmacokinetics of metronidazole was studied in 20 paediatric patients aged 6 weeks and 4 to 14 years, who had trichomonal vaginitis or an anaerobic bacterial infection. The dosage of metronidazole was about 10 or 20 mg/kg b.i.d. orally. The serum concentrations found in children and the corresponding calculated kinetic parameters were similar to those in adults after intake of an equal, weight-related dose. Metronidazole shows rapid diffusion into the saliva with a concentration ratio of about 1. 0. This can provide the basis for an efficient non-invasive method of drug monitoring.[1]


  1. Disposition kinetics of metronidazole in children. Amon, I., Amon, K., Scharp, H., Franke, G., Nagel, F. Eur. J. Clin. Pharmacol. (1983) [Pubmed]
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