The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes.

The aminopeptidase inhibitor Bestatin [2S,3R-(3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine] was tested for both in vitro and in vivo macrophage activation and antitumor activity in various experimental tumor systems including the metastasizing ESb lymphoma system. Cultures of resting macrophages were rendered nonspecifically tumoricidal for the two lymphoma sublines ESb and 721 (ESb-Cl 18.1), for the mastocytoma P815X, for LS lymphoma cells, and for proliferating lymphoblasts from DBA/2, C57BL/6J, and CBA mice by exposure to Bestatin at 50 micrograms/ml culture medium. Untreated mononuclear phagocytes and Bestatin alone were not directly cytotoxic. Treatment of mice parenterally with Bestatin also induced cytotoxic macrophages for several tumor cells when tested in vitro. Normal peritoneal mouse macrophages from untreated mice or from control mice given injections of phosphate-buffered saline were not cytotoxic. The macrophage activation to lyse tumor cells was sharply dependent on the Bestatin dose and appeared about 24 hr after injection of the dipeptide. Bestatin activates macrophages through a T-cell-independent process to lyse tumor target cells, inasmuch as macrophages from homozygous athymic nude (nu/nu) mice treated i.p. with the dipeptide were also stimulated and cytotoxic for tumor cells. We present evidence that the macrophage is the prominent host cell responsible for tumor cell destruction in animals treated with Bestatin and rule out the possibility that natural killer cells play a major role in the experiments described.[1]


  1. Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes. Schorlemmer, H.U., Bosslet, K., Sedlacek, H.H. Cancer Res. (1983) [Pubmed]
WikiGenes - Universities