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MeSH Review

Macrophage Activation

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Disease relevance of Macrophage Activation


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Chemical compound and disease context of Macrophage Activation


Biological context of Macrophage Activation


Anatomical context of Macrophage Activation


Associations of Macrophage Activation with chemical compounds


Gene context of Macrophage Activation


Analytical, diagnostic and therapeutic context of Macrophage Activation


  1. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Monney, L., Sabatos, C.A., Gaglia, J.L., Ryu, A., Waldner, H., Chernova, T., Manning, S., Greenfield, E.A., Coyle, A.J., Sobel, R.A., Freeman, G.J., Kuchroo, V.K. Nature (2002) [Pubmed]
  2. Recognition and plasma clearance of endotoxin by scavenger receptors. Hampton, R.Y., Golenbock, D.T., Penman, M., Krieger, M., Raetz, C.R. Nature (1991) [Pubmed]
  3. Tissue cytokine patterns in patients with polymyalgia rheumatica and giant cell arteritis. Weyand, C.M., Hicok, K.C., Hunder, G.G., Goronzy, J.J. Ann. Intern. Med. (1994) [Pubmed]
  4. Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Lien, E., Aukrust, P., Sundan, A., Müller, F., Frøland, S.S., Espevik, T. Blood (1998) [Pubmed]
  5. Ability of the immunomodulating dipeptide bestatin to activate cytotoxic mononuclear phagocytes. Schorlemmer, H.U., Bosslet, K., Sedlacek, H.H. Cancer Res. (1983) [Pubmed]
  6. Saliva of Rhipicephalus sanguineus tick impairs T cell proliferation and IFN-gamma-induced macrophage microbicidal activity. Ferreira, B.R., Silva, J.S. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  7. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Tanaka, T., Akira, S., Yoshida, K., Umemoto, M., Yoneda, Y., Shirafuji, N., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. Cell (1995) [Pubmed]
  8. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J., Glass, C.K. Nature (1998) [Pubmed]
  9. Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane. Thelen, M., Rosen, A., Nairn, A.C., Aderem, A. Nature (1991) [Pubmed]
  10. Role of gamma-interferon in antibody-producing responses. Leibson, H.J., Gefter, M., Zlotnik, A., Marrack, P., Kappler, J.W. Nature (1984) [Pubmed]
  11. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Hanada, T., Yoshida, H., Kato, S., Tanaka, K., Masutani, K., Tsukada, J., Nomura, Y., Mimata, H., Kubo, M., Yoshimura, A. Immunity (2003) [Pubmed]
  12. Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium. Khoo, K.H., Dell, A., Morris, H.R., Brennan, P.J., Chatterjee, D. J. Biol. Chem. (1995) [Pubmed]
  13. Influence of hypercholesterolemia and cholesterol accumulation on rabbit carrageenan granuloma macrophage activation. Kelley, J.L., Suenram, C.A., Rozek, M.M., Schwartz, C.J. Am. J. Pathol. (1988) [Pubmed]
  14. Functional transitions in macrophages during in vivo infection with Mycobacterium bovis bacillus Calmette-Guérin. Hamerman, J.A., Aderem, A. J. Immunol. (2001) [Pubmed]
  15. Tumor necrosis factor and macrophage activation are important in clearance of Nocardia brasiliensis from the livers and spleens of mice. Silva, C.L., Faccioli, L.H. Infect. Immun. (1992) [Pubmed]
  16. Suppression of macrophage activation with CNI-1493 increases survival in infant rats with systemic Haemophilus influenzae infection. Granert, C., Abdalla, H., Lindquist, L., Diab, A., Bahkiet, M., Tracey, K.J., Andersson, J. Infect. Immun. (2000) [Pubmed]
  17. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. Meng, F., Lowell, C.A. J. Exp. Med. (1997) [Pubmed]
  18. Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection. Utans, U., Arceci, R.J., Yamashita, Y., Russell, M.E. J. Clin. Invest. (1995) [Pubmed]
  19. Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice. Bezerra, J.A., Carrick, T.L., Degen, J.L., Witte, D., Degen, S.J. J. Clin. Invest. (1998) [Pubmed]
  20. Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection. Räisänen-Sokolowski, A., Mottram, P.L., Glysing-Jensen, T., Satoskar, A., Russell, M.E. J. Clin. Invest. (1997) [Pubmed]
  21. Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. Kovarik, P., Stoiber, D., Eyers, P.A., Menghini, R., Neininger, A., Gaestel, M., Cohen, P., Decker, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  22. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Soong, L., Xu, J.C., Grewal, I.S., Kima, P., Sun, J., Longley,, B.J., Ruddle, N.H., McMahon-Pratt, D., Flavell, R.A. Immunity (1996) [Pubmed]
  23. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. de Jonge, W.J., van der Zanden, E.P., The, F.O., Bijlsma, M.F., van Westerloo, D.J., Bennink, R.J., Berthoud, H.R., Uematsu, S., Akira, S., van den Wijngaard, R.M., Boeckxstaens, G.E. Nat. Immunol. (2005) [Pubmed]
  24. Low density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes. A possible mechanism of foam cell formation. Griffith, R.L., Virella, G.T., Stevenson, H.C., Lopes-Virella, M.F. J. Exp. Med. (1988) [Pubmed]
  25. Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. Yotsumoto, K., Okoshi, Y., Shibuya, K., Yamazaki, S., Tahara-Hanaoka, S., Honda, S., Osawa, M., Kuroiwa, A., Matsuda, Y., Tenen, D.G., Iwama, A., Nakauchi, H., Shibuya, A. J. Exp. Med. (2003) [Pubmed]
  26. Biological and antigenic similarities of murine interferon-gamma and macrophage-activating factor. Svedersky, L.P., Benton, C.V., Berger, W.H., Rinderknecht, E., Harkins, R.N., Palladino, M.A. J. Exp. Med. (1984) [Pubmed]
  27. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. Stein, M., Keshav, S., Harris, N., Gordon, S. J. Exp. Med. (1992) [Pubmed]
  28. Regulation of macrophage functions by L-arginine. Albina, J.E., Caldwell, M.D., Henry, W.L., Mills, C.D. J. Exp. Med. (1989) [Pubmed]
  29. Regulation of arachidonic acid metabolism by macrophage activation. Scott, W.A., Pawlowski, N.A., Murray, H.W., Andreach, M., Zrike, J., Cohn, Z.A. J. Exp. Med. (1982) [Pubmed]
  30. Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. Bianchi, M., Bloom, O., Raabe, T., Cohen, P.S., Chesney, J., Sherry, B., Schmidtmayerova, H., Calandra, T., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A., Tracey, K.J. J. Exp. Med. (1996) [Pubmed]
  31. Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium. Tsunawaki, S., Nathan, C.F. J. Exp. Med. (1986) [Pubmed]
  32. Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3). Ding, A., Wright, S.D., Nathan, C. J. Exp. Med. (1987) [Pubmed]
  33. Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. Wilson, C.B., Westall, J., Johnston, L., Lewis, D.B., Dower, S.K., Alpert, A.R. J. Clin. Invest. (1986) [Pubmed]
  34. Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. Eliopoulos, A.G., Dumitru, C.D., Wang, C.C., Cho, J., Tsichlis, P.N. EMBO J. (2002) [Pubmed]
  35. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. O'Farrell, A.M., Liu, Y., Moore, K.W., Mui, A.L. EMBO J. (1998) [Pubmed]
  36. Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis. Russell, M.E., Hancock, W.W., Akalin, E., Wallace, A.F., Glysing-Jensen, T., Willett, T.A., Sayegh, M.H. J. Clin. Invest. (1996) [Pubmed]
  37. Animal models in cancer research which could be useful in studies of the effect of alcohol on cellular immunity. Chirigos, M.A., Schultz, R.M. Cancer Res. (1979) [Pubmed]
  38. Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis. Leech, M., Metz, C., Santos, L., Peng, T., Holdsworth, S.R., Bucala, R., Morand, E.F. Arthritis Rheum. (1998) [Pubmed]
  39. Coronary sinus sampling of cytokines after heart transplantation: evidence for macrophage activation and interleukin-4 production within the graft. Fyfe, A., Daly, P., Galligan, L., Pirc, L., Feindel, C., Cardella, C. J. Am. Coll. Cardiol. (1993) [Pubmed]
  40. Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism. Ikezumi, Y., Atkins, R.C., Nikolic-Paterson, D.J. J. Am. Soc. Nephrol. (2003) [Pubmed]
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