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A constituent of Pterocarpus marsupium, (-)-epicatechin, as a potential antidiabetic agent.

An active constituent of Pterocarpus marsupium, (-)-epicatechin (1), has been reported to reverse hyperglycemia in alloxan diabetic rats when given before or within 24 hr after the dose of alloxan. However, when doses of (-)-epicatechin (30 mg/kg, i.p., twice daily for 3 days) are begun 92 hr after alloxan, there is no significant difference in blood glucose levels between control and (-)-epicatechin treated rats. These data suggest that, although (-)-epicatechin may protect against alloxan toxicity under certain conditions, the usefulness of (-)-epicatechin appears minimal in the treatment of already established diabetic states.[1]

References

  1. A constituent of Pterocarpus marsupium, (-)-epicatechin, as a potential antidiabetic agent. Sheehan, E.W., Zemaitis, M.A., Slatkin, D.J., Schiff, P.L. J. Nat. Prod. (1983) [Pubmed]
 
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