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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of amnioscopy on concentrations of prostaglandin F2 alpha, prostacyclin and thromboxane in maternal plasma.

To study whether amnioscopy causes a local release of prostaglandins (PG), the peripheral plasma concentrations of 13,14-dihydro-15-keto-PGF2 alpha (M-PGF2 alpha)(a metabolite of PGF2 alpha), 6-keto-PGF1 alpha (a metabolite of prostacyclin) and thromboxane B2 (a metabolite of thromboxane A2) were measured with radioimmunoassays in 12 women between 36 and 40 weeks of pregnancy before and after amnioscopy. The levels of M-PGF2 alpha and thromboxane B2 rose significantly between 10 and 30 min after amnioscopy but dropped to pre-amnioscopy levels within 60 min, whereas the 6-keto-PGF1 alpha concentration did not change. These findings suggest a local release of PGF2 alpha and Tx-A2 in the myometrium and/or intrauterine tissues as a consequence of amnioscopy.[1]


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