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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Elevation of colony stimulating factors in mouse serum after injection of PSK, an antitumor polysaccharide.

The level of colony stimulating factors ( CSF) in mouse serum was elevated by a single intraperitoneal injection of PSK, a host-mediated antitumor protein-bound polysaccharide obtained from Basidiomycetes. The assay for CSF activity was performed by employing a semisolid methylcellulose culture method using mouse bone marrow cells, and the activity was estimated by an equation well matched with the dose response curve obtained in the CSF assay. A temporary increase of CSF activity within 10 h after the injection of an antitumor polysaccharide, Krestin (PSK) (250-1000 mg/kg) was followed by a fast decline in the activity, but no significant increases were detected in the cases of 62.5 and 125 mg/kg PSK injections. The CSF activity in PSK (500 mg/kg)-treated mouse serum was separated into two active fractions by DEAE ion-exchange chromatography, and both fractions were found to induce colonies comprised of cells with the properties of macrophage in regard to morphology, cytochemistry of non-specific esterase, phagocytic function and expression of Fc receptors on the cell surface. The elevation of the serum CSF level due to administration of so-called host-mediated antitumor agents might be one of the tumor-defense mechanisms in vivo.[1]


  1. Elevation of colony stimulating factors in mouse serum after injection of PSK, an antitumor polysaccharide. Satoh, M., Ichimura, O., Mitsuno, T., Kojima, E., Osawa, T. J. Pharmacobio-dyn. (1982) [Pubmed]
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