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MeSH Review


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Disease relevance of Histocytochemistry


High impact information on Histocytochemistry

  • Here we report single gene detection with a procedure using 2-acetylaminofluorene (AAF)-modified probes, immunoperoxidase cytochemistry and reflection-contrast microscopy [6].
  • The nonhemoglobinized bursts, induced by FVA, were established to be erythroid by cytochemistry, electron microscopy, and hormone sensitivity [7].
  • Cytochemistry confirmed that estradiol caused no alteration in the handling of tracer [8].
  • The dynamic intra-nuclear localization of MRP RNA, the RNA component of the ribonucleoprotein enzyme RNase MRP, was examined in living cells by the method of fluorescent RNA cytochemistry (Wang, J., L.-G. Cao, Y.-L. Wang, and T. Pederson. 1991. Proc. Natl. Acad. Sci. USA. 88:7391-7395) [9].
  • We have used expression of HRP from cDNA in a variety of cells in combination with peroxidase cytochemistry to outline traffic into and out of the Golgi apparatus at the electron microscopic level with very high sensitivity [10].

Chemical compound and disease context of Histocytochemistry


Biological context of Histocytochemistry


Anatomical context of Histocytochemistry


Associations of Histocytochemistry with chemical compounds

  • This sorting process was analyzed using 3,3'-diaminobenzidine (DAB) cytochemistry, followed by Percoll density gradient cell fractionation [25].
  • Combination of preembedding thiamine pyrophosphatase cytochemistry, with postembedding immunostaining for galactosyltransferase proved codistribution of the two enzymes [26].
  • By combining the techniques of protein A-gold immunocytochemistry and ricin-gold affinity cytochemistry we have demonstrated colocalization of the lysosomal enzyme alpha-mannosidase with gal/galNAc polysaccharides in prespore vesicles and the spore coat [27].
  • DAB cytochemistry showed that sorting between endocytosed 131I-transferrin and 125I-ASOR/HRP was also blocked in the presence of primaquine [25].
  • Evidence for Golgi apparatus-associated processing of oligosaccharides in the ER was obtained by lectin-gold cytochemistry revealing the presence of the galactose (beta 1----4)N-acetylglucosamine sequence and sialic acid residues [28].

Gene context of Histocytochemistry

  • The msg1 protein was localized to the melanocyte nucleus by immunofluorescence cytochemistry [29].
  • Immunofluorescence cytochemistry performed on cultured alveolar type II cells showed that Rab38 distributed extensively in the cytoplasm with a distribution pattern similar to endoplasmic reticulum rather than other subcellular organelles [30].
  • Judged by quantitative immunogold cytochemistry, deletion of the alpha-syntrophin gene causes a partial loss (by 70%) of aquaporin-4 labeling at astrocyte and Müller cell endfeet but no decrease in Kir4.1 labeling at these sites [31].
  • The method described here has been applied to studies of human EPO deficiency and proved to be successful in the identification of individuals with partial EPO deficiency, which is not feasible with non quantitative methods (for example, cytochemistry) or unselective biochemical assay of peroxidase activity [32].
  • By immunogold cytochemistry, it could be demonstrated that the MCT2 immunosignal was concentrated at postsynaptic densities of parallel fiber-Purkinje cell synapses [33].

Analytical, diagnostic and therapeutic context of Histocytochemistry


  1. Electron microscopic and cytochemical observations of theophylline and melanocyte-stimulating hormone effects on melanoma cells in culture. Hu, F., Mah, K., Teramura, D.J. Cancer Res. (1982) [Pubmed]
  2. Estrogen protects the inner retina from apoptosis and ischemia-induced loss of Vesl-1L/Homer 1c immunoreactive synaptic connections. Kaja, S., Yang, S.H., Wei, J., Fujitani, K., Liu, R., Brun-Zinkernagel, A.M., Simpkins, J.W., Inokuchi, K., Koulen, P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  3. Measurement of myeloid maturation by flow cytochemistry in HL-60 leukemia: esterase is inducible, myeloperoxidase is not. Ross, D.W. Cytometry. (1986) [Pubmed]
  4. Esterase cytochemistry in primary myelodysplastic syndromes and megaloblastic anaemias: demonstration of abnormal staining patterns associated with dysmyelopoiesis. Scott, C.S., Cahill, A., Bynoe, A.G., Ainley, M.J., Hough, D., Roberts, B.E. Br. J. Haematol. (1983) [Pubmed]
  5. Morphometric analysis of envelope glycoprotein gp120 distribution on HIV-1 virions. Hart, T.K., Klinkner, A.M., Ventre, J., Bugelski, P.J. J. Histochem. Cytochem. (1993) [Pubmed]
  6. Chromosomal localization of a unique gene by non-autoradiographic in situ hybridization. Landegent, J.E., Jansen in de Wal, N., van Ommen, G.J., Baas, F., de Vijlder, J.J., van Duijn, P., Van der Ploeg, M. Nature (1985) [Pubmed]
  7. Increased erythropoietin sensitivity after in vitro transformation of hematopoietic precursors by RNA tumor viruses. Hankins, W.D. J. Natl. Cancer Inst. (1983) [Pubmed]
  8. Hepatic handling of bile salts and protein in the rat during intrahepatic cholestasis. Goldsmith, M.A., Huling, S., Jones, A.L. Gastroenterology (1983) [Pubmed]
  9. Dynamic localization of RNase MRP RNA in the nucleolus observed by fluorescent RNA cytochemistry in living cells. Jacobson, M.R., Cao, L.G., Wang, Y.L., Pederson, T. J. Cell Biol. (1995) [Pubmed]
  10. Transport into and out of the Golgi complex studied by transfecting cells with cDNAs encoding horseradish peroxidase. Connolly, C.N., Futter, C.E., Gibson, A., Hopkins, C.R., Cutler, D.F. J. Cell Biol. (1994) [Pubmed]
  11. Ischemic disruption of glutamate homeostasis in brain: quantitative immunocytochemical analyses. Ottersen, O.P., Laake, J.H., Reichelt, W., Haug, F.M., Torp, R. J. Chem. Neuroanat. (1996) [Pubmed]
  12. Recently recognized congenital myasthenic syndromes: (a) end-plate acetylcholine (ACh) esterase deficiency (b) putative abnormality of the ACh induced ion channel (c) putative defect of ACh resynthesis or mobilization - clinical features, ultrastructure and cytochemistry. Engel, A.G., Lambert, E.H., Mulder, D.M., Gomez, M.R., Whitaker, J.N., Hart, Z., Sahashi, K. Ann. N. Y. Acad. Sci. (1981) [Pubmed]
  13. Tetrahydrofolate dehydrogenase cytochemistry in acute lymphoblastic leukemia. Invernizzi, R., Nano, R., Perugini, O., De Fazio, P., Nespoli, L., Gerzeli, G., Ascari, E. Eur. J. Haematol. (1988) [Pubmed]
  14. Heterogeneous localization of adenylate and guanylate cyclases in R3230AC rat mammary adenocarcinoma cells. Hwang, B.H., Liu, D.K. Virchows Arch., B, Cell Pathol. (1985) [Pubmed]
  15. The corpus luteum of the guinea pig. III. Cytochemical studies on the Golgi complex and GERL during normal postpartum regression of luteal cells, emphasizing the origin of lysosomes and autophagic vacuoles. Paavola, L.G. J. Cell Biol. (1978) [Pubmed]
  16. Molecular chaperones in pancreatic tissue: the presence of cpn10, cpn60 and hsp70 in distinct compartments along the secretory pathway of the acinar cells. Vélez-Granell, C.S., Arias, A.E., Torres-Ruíz, J.A., Bendayan, M. J. Cell. Sci. (1994) [Pubmed]
  17. Localization of "transcriptively active" cells during odontogenesis using acridine orange ultrastructural cytochemistry. Lehmann, R., Slavkin, H.C. Dev. Biol. (1976) [Pubmed]
  18. Reduced-size liver transplantation in the mouse. Conzelmann, L.O., Zhong, Z., Bunzendahl, H., Wheeler, M.D., Lemasters, J.J. Transplantation (2003) [Pubmed]
  19. Partial characterization of lectin binding sites of retinal photoreceptor outer segments and interphotoreceptor matrix. Wood, J.G., Besharse, J.C., Napier-Marshall, L. J. Comp. Neurol. (1984) [Pubmed]
  20. Shift of equilibrium density induced by 3,3'-diaminobenzidine cytochemistry: a new procedure for the analysis and purification of peroxidase-containing organelles. Courtoy, P.J., Quintart, J., Baudhuin, P. J. Cell Biol. (1984) [Pubmed]
  21. Redistribution of mannose-6-phosphate receptors induced by tunicamycin and chloroquine. Brown, W.J., Constantinescu, E., Farquhar, M.G. J. Cell Biol. (1984) [Pubmed]
  22. Morphological and biochemical studies on the development of cholinergic properties in cultured sympathetic neurons. I. Correlative changes in choline acetyltransferase and synaptic vesicle cytochemistry. Johnson, M.I., Ross, C.D., Meyers, M., Spitznagel, E.L., Bunge, R.P. J. Cell Biol. (1980) [Pubmed]
  23. Detection of desmin-containing intermediate filaments in cultured muscle and nonmuscle cells by immunoelectron microscopy. Ip, W., Danto, S.I., Fischman, D.A. J. Cell Biol. (1983) [Pubmed]
  24. Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes. Nagelhus, E.A., Mathiisen, T.M., Bateman, A.C., Haug, F.M., Ottersen, O.P., Grubb, J.H., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  25. Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells. Stoorvogel, W., Geuze, H.J., Strous, G.J. J. Cell Biol. (1987) [Pubmed]
  26. Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae. Roth, J., Berger, E.G. J. Cell Biol. (1982) [Pubmed]
  27. Developing Dictyostelium cells contain the lysosomal enzyme alpha-mannosidase in a secretory granule. Lenhard, J.M., Siegel, A., Free, S.J. J. Cell Biol. (1989) [Pubmed]
  28. DS28-6, a temperature-sensitive mutant of Chinese hamster ovary cells, expresses key phenotypic changes associated with brefeldin A treatment. Zuber, C., Roth, J., Misteli, T., Nakano, A., Moremen, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  29. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. Shioda, T., Fenner, M.H., Isselbacher, K.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  30. Expression and localization of a novel Rab small G protein (Rab38) in the rat lung. Osanai, K., Iguchi, M., Takahashi, K., Nambu, Y., Sakuma, T., Toga, H., Ohya, N., Shimizu, H., Fisher, J.H., Voelker, D.R. Am. J. Pathol. (2001) [Pubmed]
  31. Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice. Puwarawuttipanit, W., Bragg, A.D., Frydenlund, D.S., Mylonakou, M.N., Nagelhus, E.A., Peters, M.F., Kotchabhakdi, N., Adams, M.E., Froehner, S.C., Haug, F.M., Ottersen, O.P., Amiry-Moghaddam, M. Neuroscience (2006) [Pubmed]
  32. Oxidation of homovanillic acid as a selective assay for eosinophil peroxidase in eosinophil peroxidase-myeloperoxidase mixtures and its use in the detection of human eosinophil peroxidase deficiency. Menegazzi, R., Zabucchi, G., Zuccato, P., Cramer, R., Piccinini, C., Patriarca, P. J. Immunol. Methods (1991) [Pubmed]
  33. A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Bergersen, L., Waerhaug, O., Helm, J., Thomas, M., Laake, P., Davies, A.J., Wilson, M.C., Halestrap, A.P., Ottersen, O.P. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2001) [Pubmed]
  34. Purine nucleoside phosphorylase is associated with centrioles and basal bodies. Oliver, J.M., Osborne, W.R., Pfeiffer, J.R., Child, F.M., Berlin, R.D. J. Cell Biol. (1981) [Pubmed]
  35. Myeloperoxidase: expression and modulation in a large panel of human leukemia-lymphoma cell lines. Hu, Z.B., Ma, W., Uphoff, C.C., Metge, K., Gignac, S.M., Drexler, H.G. Blood (1993) [Pubmed]
  36. Observations with cytochemistry and ultracryotomy on the fine structure of the expanding walls in actively elongating plant cells. Roland, J.C., Vian, B., Reis, D. J. Cell. Sci. (1975) [Pubmed]
  37. Cholesterol, phospholipid, and protein changes in focal opacities in the human eye lens. Duindam, J.J., Vrensen, G.F., Otto, C., Greve, J. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  38. Enterochromaffin-like cells, a cellular source of uroguanylin in rat stomach. Date, Y., Nakazato, M., Yamaguchi, H., Kangawa, K., Kinoshita, Y., Chiba, T., Ueta, Y., Yamashita, H., Matsukura, S. Endocrinology (1999) [Pubmed]
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