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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A study of thyroid function in psychiatric in-patients.

The prevalence of abnormal serum total thyroxine (T4) and triiodothyronine (T3) concentrations were determined in 1,206 in-patients in two associated psychiatric hospitals. The biochemical pattern of primary hypothyroidism occurred in five females and one male (prevalence 0.5 per cent), but in only one patient was the diagnosis clinically obvious. Eight patients (all female) were clinically hyperthyroid (prevalence 0.7 per cent), of whom six were previously undiagnosed. There was no evidence that phenothiazines or benzodiazepine therapy had any significant effect on thyroid hormone levels. The small differences in thyroid hormone levels between psychiatric diagnostic groups could be explained by differences in age distribution.[1]


  1. A study of thyroid function in psychiatric in-patients. McLarty, D.G., Ratcliffe, W.A., Ratcliffe, J.G., Shimmins, J.G., Goldberg, A. The British journal of psychiatry : the journal of mental science. (1978) [Pubmed]
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