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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Age Distribution

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Disease relevance of Age Distribution


Psychiatry related information on Age Distribution


High impact information on Age Distribution


Chemical compound and disease context of Age Distribution


Biological context of Age Distribution

  • Although more of the blacks were male, the age distribution, midarm circumference, midarm muscle circumference, blood pressure, and serum calcium, phosphorus, and PTH concentrations were comparable in the two groups [17].
  • Criticism of these methods (e.g. see Cooper, this issue, pp. 266-269, ) suggests that these studies are flawed, and posits that such methodologies cannot be used to study the cell cycle because they alter the size and age distributions of the cultures [18].
  • This behaviour is similar to that which we observed (Pompei and Wilson, 2001) in the Surveillance, Epidemiology, and End Results (SEER) data where the age distribution of human cancer incidence turns over at about age 80 [19].
  • The autocatalyzed progression of aneuploidy accounts for all cancer-specific phenotypes, the Hayflick limit of cultured cells, carcinogen-induced tumors in mice, the age distribution of human cancer, and multidrug-resistance [20].
  • The time course of creatine influx or efflux as measured in populations of red cells or red cell ghosts with normal age distribution does not follow simple two-compartment kinetics [21].

Anatomical context of Age Distribution


Associations of Age Distribution with chemical compounds

  • Pentosidine and fluorescent AGE distributions of diabetic RBM were similar to LBM, but the CML AGE in diabetic kidney was less in the triple helical domain than in NC1 [23].
  • The small differences in thyroid hormone levels between psychiatric diagnostic groups could be explained by differences in age distribution [24].
  • The purpose of this study was to validate the relationship of warfarin sodium and CCR, as well as to present the appearance and sex and age distribution of the normal degenerative CCR seen in the elderly [25].
  • The fact that many aging curves such as those for estrogen, testosterone or 17-hydroxycorticosteroid show striking similarity to the MS incidence curves raises the question whether infection is the entire explanation for the age distribution [26].
  • Carbonyls in samples taken after steroid administration were less than for controls with a similar age distribution [27].

Gene context of Age Distribution

  • EXPERIMENTAL DESIGN: We performed a systematic review of ovarian tumors from 178 BRCA1 mutation carriers, 29 BRCA2 mutation carriers, and 235 controls with a similar age distribution [28].
  • In contrast to that observed in Caucasian patients, no significant difference was observed in the age distribution and the frequency of EGFR overexpression/amplification between primary and secondary GBMs in adult Chinese patients [29].
  • The absolute rate of ER+ breast cancer (standardized to the age distribution of person-years experienced by all study participants using 5-year age categories) was 232 per 100,000 person-years among women in the highest category of alcohol intake, and 158 per 100,000 person-years among nondrinkers [30].
  • The age distribution at diagnosis of sporadic patients was significantly higher than that of FAP and HNPCC patients (median 60 years vs. 43 and 49 years; p < 0.0001) [31].
  • No studies have assessed the age distribution of AMACR expression in normal men [32].

Analytical, diagnostic and therapeutic context of Age Distribution


  1. Gastric lesion in dermatitis herpetiformis. O'Donoghue, D.P., Lancaster-Smith, M., Johnson, G.D., Kumar, P.J. Gut (1976) [Pubmed]
  2. Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance. Secker-Walker, L.M., Craig, J.M., Hawkins, J.M., Hoffbrand, A.V. Leukemia (1991) [Pubmed]
  3. The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer. Spurdle, A.B., Goodwin, B., Hodgson, E., Hopper, J.L., Chen, X., Purdie, D.M., McCredie, M.R., Giles, G.G., Chenevix-Trench, G., Liddle, C. Pharmacogenetics (2002) [Pubmed]
  4. Age-specific risks of varicella complications. Preblud, S.R. Pediatrics (1981) [Pubmed]
  5. The value of quantitative 99M technetium dimercaptosuccinic acid renal scintigraphy for predicting postoperative renal insufficiency in patients undergoing nephrectomy. Mullerad, M., Kastin, A., Issaq, E., Moskovitz, B., Groshar, D., Nativ, O. J. Urol. (2003) [Pubmed]
  6. Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology. Münch, G., Apelt, J., Rosemarie-Kientsch-Engel, n.u.l.l., Stahl, P., Lüth, H.J., Schliebs, R. J. Neurochem. (2003) [Pubmed]
  7. Prevalence and associated features of epilepsy in adults with Down's syndrome. McVicker, R.W., Shanks, O.E., McClelland, R.J. The British journal of psychiatry : the journal of mental science. (1994) [Pubmed]
  8. Early detection of prostate cancer. Part I: Prior probability and effectiveness of tests. The American College of Physicians. Coley, C.M., Barry, M.J., Fleming, C., Mulley, A.G. Ann. Intern. Med. (1997) [Pubmed]
  9. Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City. Tang, M.X., Maestre, G., Tsai, W.Y., Liu, X.H., Feng, L., Chung, W.Y., Chun, M., Schofield, P., Stern, Y., Tycko, B., Mayeux, R. Am. J. Hum. Genet. (1996) [Pubmed]
  10. A prospective randomized trial of pretransfusion/azathioprine/prednisone versus cyclosporine/prednisone immunosuppression in cardiac transplant recipients: preliminary results. Barnhart, G.R., Hastillo, A., Goldman, M.H., Szentpetery, S., Wolfgang, T.C., Mohanakumar, T., Katz, M.R., Rider, S., Hanrahan, J., Lower, R.R. Circulation (1985) [Pubmed]
  11. Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene. Akasaka, T., Akasaka, H., Ueda, C., Yonetani, N., Maesako, Y., Shimizu, A., Yamabe, H., Fukuhara, S., Uchiyama, T., Ohno, H. J. Clin. Oncol. (2000) [Pubmed]
  12. Studies of murine large granular lymphocytes. II. Tissue, strain, and age distributions of LGL and LAL. Itoh, K., Suzuki, R., Umezu, Y., Hanaumi, K., Kumagai, K. J. Immunol. (1982) [Pubmed]
  13. Concentrations of lead, cadmium and zinc in the tissues of reproductive organs of men. Oldereid, N.B., Thomassen, Y., Attramadal, A., Olaisen, B., Purvis, K. J. Reprod. Fertil. (1993) [Pubmed]
  14. Significance of follow-up mammography in estimating the effect of tamoxifen in breast cancer patients who have undergone surgery. Son, H.J., Oh, K.K. AJR. American journal of roentgenology. (1999) [Pubmed]
  15. Rheumatic fever: clinical and laboratory manifestations in a New Zealand community. Stanhope, J.M., Clarkson, P.M., Philipp, R. N. Z. Med. J. (1979) [Pubmed]
  16. Complications of oral anticoagulant therapy: bleeding and nonbleeding, rates and risk factors. Hylek, E.M. Seminars in vascular medicine. (2003) [Pubmed]
  17. The relationship between calcium, phosphorus, and sodium intake, race, and blood pressure in children with renal insufficiency: a report of the Growth Failure in Children with Renal Diseases (GFRD) Study. Trachtman, H., Chan, J.C., Boyle, R., Farina, D., Baluarte, H.J., Chinchilli, V.M., Dresner, I.G., Feld, L.G. J. Am. Soc. Nephrol. (1995) [Pubmed]
  18. Reply: whole-culture synchronization - effective tools for cell cycle studies. Spellman, P.T., Sherlock, G. Trends Biotechnol. (2004) [Pubmed]
  19. Age distribution of cancer in mice: the incidence turnover at old age. Pompei, F., Polkanov, M., Wilson, R. Toxicology and industrial health. (2001) [Pubmed]
  20. Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapy. Rasnick, D. Cancer Genet. Cytogenet. (2002) [Pubmed]
  21. Creatine and creatinine transport in old and young human red blood cells. Ku, C.P., Passow, H. Biochim. Biophys. Acta (1980) [Pubmed]
  22. Sialic acid content of erythrocytes in uremic patients. Correlation with the age distribution of erythrocytes as assessed by glutamic oxaloacetic transaminase determination. Gafter, U., Levinsky, H., Malachi, T., Levi, J., Bogin, E., Allalouf, D. Nephron (1985) [Pubmed]
  23. Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility. Mott, J.D., Khalifah, R.G., Nagase, H., Shield, C.F., Hudson, J.K., Hudson, B.G. Kidney Int. (1997) [Pubmed]
  24. A study of thyroid function in psychiatric in-patients. McLarty, D.G., Ratcliffe, W.A., Ratcliffe, J.G., Shimmins, J.G., Goldberg, A. The British journal of psychiatry : the journal of mental science. (1978) [Pubmed]
  25. Tracheal and bronchial cartilaginous rings: warfarin sodium-induced calcification. Moncada, R.M., Venta, L.A., Venta, E.R., Fareed, J., Walenga, J.M., Messmore, H.L. Radiology. (1992) [Pubmed]
  26. Multiple sclerosis: a two-stage process? Fischman, H.R. Am. J. Epidemiol. (1981) [Pubmed]
  27. Elevated protein carbonyls and lipid peroxidation products correlating with myeloperoxidase in tracheal aspirates from premature infants. Buss, I.H., Darlow, B.A., Winterbourn, C.C. Pediatr. Res. (2000) [Pubmed]
  28. Pathology of ovarian cancers in BRCA1 and BRCA2 carriers. Lakhani, S.R., Manek, S., Penault-Llorca, F., Flanagan, A., Arnout, L., Merrett, S., McGuffog, L., Steele, D., Devilee, P., Klijn, J.G., Meijers-Heijboer, H., Radice, P., Pilotti, S., Nevanlinna, H., Butzow, R., Sobol, H., Jacquemier, J., Lyonet, D.S., Neuhausen, S.L., Weber, B., Wagner, T., Winqvist, R., Bignon, Y.J., Monti, F., Schmitt, F., Lenoir, G., Seitz, S., Hamman, U., Pharoah, P., Lane, G., Ponder, B., Bishop, D.T., Easton, D.F. Clin. Cancer Res. (2004) [Pubmed]
  29. Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway. Xie, D., Zeng, Y.X., Wang, H.J., Tai, L.S., Wen, J.M., Tao, Y., Ma, N.F., Hu, L., Sham, J.S., Guan, X.Y. Acta Neuropathol. (2005) [Pubmed]
  30. Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: a prospective cohort study. Suzuki, R., Ye, W., Rylander-Rudqvist, T., Saji, S., Colditz, G.A., Wolk, A. J. Natl. Cancer Inst. (2005) [Pubmed]
  31. Survival of patients with hereditary colorectal cancer: comparison of HNPCC and colorectal cancer in FAP patients with sporadic colorectal cancer. Bertario, L., Russo, A., Sala, P., Eboli, M., Radice, P., Presciuttini, S., Andreola, S., Rodriguez-Bigas, M.A., Pizzetti, P., Spinelli, P. Int. J. Cancer (1999) [Pubmed]
  32. Age-associated changes in alpha-methyl CoA racemase (AMACR) expression in nonneoplastic prostatic tissues. Gologan, A., Bastacky, S., McHale, T., Yu, J., Cai, C., Monzon-Bordonaba, F., Dhir, R. Am. J. Surg. Pathol. (2005) [Pubmed]
  33. Late effects in ankylosing spondylitis patients treated with 224Ra. Wick, R.R., Nekolla, E.A., Gössner, W., Kellerer, A.M. Radiat. Res. (1999) [Pubmed]
  34. The prevalence of MDMA/MDA in both hair and urine in drug users. Han, E., Yang, W., Lee, J., Park, Y., Kim, E., Lim, M., Chung, H. Forensic Sci. Int. (2005) [Pubmed]
  35. New National Cholesterol Education Program III guidelines for primary prevention lipid-lowering drug therapy: projected impact on the size, sex, and age distribution of the treatment-eligible population. Fedder, D.O., Koro, C.E., L'Italien, G.J. Circulation (2002) [Pubmed]
  36. Cost-effectiveness of vaccination against invasive pneumococcal disease among people 50 through 64 years of age: role of comorbid conditions and race. Sisk, J.E., Whang, W., Butler, J.C., Sneller, V.P., Whitney, C.G. Ann. Intern. Med. (2003) [Pubmed]
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