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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Benoxaprofen kinetics in renal impairment.

To establish therapeutic guidelines, benoxaprofen kinetics were examined in 26 adult subjects with normal and decreased renal function. Mean peak plasma concentrations after a single 600-mg dose ranged from 58 to 72 mg/l, independent of renal function. Elimination half-life and benoxaprofen plasma clearance correlated with creatinine clearance. Hemodialysis did not remove benoxaprofen from plasma. A dosage nomogram was derived from which a dose one half of the normal maintenance dose was suggested for patients with severe renal failure.[1]


  1. Benoxaprofen kinetics in renal impairment. Aronoff, G.R., Ozawa, T., DeSante, K.A., Nash, J.F., Ridolfo, A.S. Clin. Pharmacol. Ther. (1982) [Pubmed]
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