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Chemical Compound Review

Inflamid     2-[2-(4- chlorophenyl)benzooxazol-5...

Synonyms: Coxigon, Oraflex, Uniprofen, Opren, Benoxaprofen, ...
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Disease relevance of Oraflex


High impact information on Oraflex


Chemical compound and disease context of Oraflex


Biological context of Oraflex


Anatomical context of Oraflex


Associations of Oraflex with other chemical compounds


Gene context of Oraflex

  • Agents that inhibit lipoxygenase activity, i.e. nordihydroguaiaretic acid, benoxaprofen, but not agents that are cyclooxygenase inhibitors, i.e. indomethacin, are effective in suppressing the oxidant response to TPA [26].
  • A number of specific chemical problems are discussed, including the safety evaluation of benzene, methylene dichloride, DDT, dieldrin, TCDD, the PCBs, and the hepatotoxic drugs: benoxaprofen and tienilic acid [27].
  • The pathophysiologic significance of increased levels of lipoxygenase compounds in psoriatic lesions was assessed in a double-blind randomized clinical study with the 5-lipoxygenase inhibitor, benoxaprofen [28].
  • Moreover, enantioselective cleavage of the formed benoxaprofen glucuronides by alkaline hydrolysis, hydrolytic enzymes, and acyl migration must be controlled for both in vitro and in vivo studies since R-benoxaprofen glucuronide is degraded faster than the S-diastereomer under certain conditions [29].
  • The solid-state 13C-NMR spectra of the polymorphs of benoxaprofen, nabilone, and cefazolin are reported using the cross-polarization/magic-angle spinning (CP/MAS) technique [30].

Analytical, diagnostic and therapeutic context of Oraflex


  1. Benoxaprofen suppression of polychlorinated biphenyl toxicity without alteration of mixed function oxidase function. Rifkind, A.B., Muschick, H. Nature (1983) [Pubmed]
  2. Photosensitization to benoxaprofen not due to ultraviolet A alone. Fenton, D.A., Wilkinson, J.D., English, J.S. Lancet (1981) [Pubmed]
  3. Transient neutropenia due to benoxaprofen. Essigman, W.K., Williams, J.R. Lancet (1980) [Pubmed]
  4. Bullous dermatitis associated with benoxaprofen. du Vivier, A. Lancet (1982) [Pubmed]
  5. Transient neutropenia and thrombocytopenia due to benoxaprofen. Leen, C., Gibb, A.P., Brettle, R.P., Welsby, P.D. Lancet (1982) [Pubmed]
  6. Benoxaprofen, a potent inhibitor of monocyte/endothelial-cell interaction. Brown, K.A., Ferrie, J., Wilbourn, B., Dumonde, D.C. Lancet (1984) [Pubmed]
  7. Promotion of DNA strand breaks in cocultured mononuclear leukocytes by protein kinase C-dependent prooxidative interactions of benoxaprofen, human polymorphonuclear leukocytes, and ultraviolet radiation. Schwalb, G., Beyers, A.D., Anderson, R., Nel, A.E. Cancer Res. (1988) [Pubmed]
  8. Naproxen pharmacokinetics in the elderly. Upton, R.A., Williams, R.L., Kelly, J., Jones, R.M. British journal of clinical pharmacology. (1984) [Pubmed]
  9. A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. Mungavin, J.M., Clarke, T.K. Current medical research and opinion. (1983) [Pubmed]
  10. Activated osteoarthrosis (osteoarthritis) and its treatment with indomethacin and benoxaprofen: a double-blind crossover study. Bach, G.L. European journal of rheumatology and inflammation. (1982) [Pubmed]
  11. Toxic epidermal necrolysis in a patient treated with gold salts and benoxaprofen. Feldman, C., Lampert, I., Parke, A. Rheumatology and rehabilitation. (1982) [Pubmed]
  12. Relative toxicities of several nonsteroidal antiinflammatory compounds in primary cultures of rat hepatocytes. Sorensen, E.M., Acosta, D. Journal of toxicology and environmental health. (1985) [Pubmed]
  13. Benoxaprofen kinetics in renal impairment. Aronoff, G.R., Ozawa, T., DeSante, K.A., Nash, J.F., Ridolfo, A.S. Clin. Pharmacol. Ther. (1982) [Pubmed]
  14. Plasma protein binding and interaction studies with benoxaprofen. Chatfield, D.H., Green, J.N., Kao, J.C., Tarrant, M.E., Woodage, T.J. Biochem. Pharmacol. (1978) [Pubmed]
  15. Effects of benoxaprofen on human neutrophil function. Turner, R.A., Semble, E.L., Johnson, J.A., McCrickard, E.L., Treadway, W.J., Kaufmann, J.S. J. Rheumatol. (1984) [Pubmed]
  16. Fluorimetric determination of the quaternary compound trospium and its metabolite in biological material after derivatization with benoxaprofen chloride. Schladitz-Keil, G., Spahn, H., Mutschler, E. J. Chromatogr. (1985) [Pubmed]
  17. Benoxaprofen-induced photo-onycholysis. McCormack, L.S., Elgart, M.L., Turner, M.L. J. Am. Acad. Dermatol. (1982) [Pubmed]
  18. Selective immobilization of human mononuclear phagocytes by benoxaprofen. Goetzl, E.J., Valone, F.H. Arthritis Rheum. (1982) [Pubmed]
  19. Benoxaprofen stimulates proteoglycan synthesis in normal canine knee cartilage in vitro. Palmoski, M.J., Brandt, K.D. Arthritis Rheum. (1983) [Pubmed]
  20. Benoxaprofen photosensitization of cell membrane disruption. Kochevar, I.E., Hoover, K.W., Gawienowski, M. J. Invest. Dermatol. (1984) [Pubmed]
  21. Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity. Ayrton, A.D., Ioannides, C., Parke, D.V. Biochem. Pharmacol. (1991) [Pubmed]
  22. Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo-oxygenase products in rat skin allografts. Fan, T.P., Lewis, G.P. Br. J. Pharmacol. (1984) [Pubmed]
  23. Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid. Burka, J.F. Br. J. Pharmacol. (1985) [Pubmed]
  24. Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. Tornhamre, S., Edenius, C., Smedegård, G., Sjöquist, B., Lindgren, J.A. Eur. J. Pharmacol. (1989) [Pubmed]
  25. A comparative study of the photochemistry of the non-steroidal anti-inflammatory drugs, naproxen, benoxaprofen and indomethacin. Moore, D.E., Chappuis, P.P. Photochem. Photobiol. (1988) [Pubmed]
  26. Reactive oxygen in the tumor promotion stage of skin carcinogenesis. Fischer, S.M., Cameron, G.S., Baldwin, J.K., Jasheway, D.W., Patrick, K.E. Lipids (1988) [Pubmed]
  27. Current problems in the evaluation of chemical safety. Parke, D.V., Ioannides, C., Lewis, D.F., Obrebska-Parke, M.J. Polish journal of occupational medicine. (1990) [Pubmed]
  28. Benoxaprofen improves psoriasis. A double-blind study. Kragballe, K., Herlin, T. Archives of dermatology. (1983) [Pubmed]
  29. Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides. Spahn, H., Iwakawa, S., Lin, E.T., Benet, L.Z. Pharm. Res. (1989) [Pubmed]
  30. Analysis of solid-state Carbon-13 NMR spectra of polymorphs (benoxaprofen and nabilone) and pseudopolymorphs (cefazolin). Byrn, S.R., Gray, G., Pfeiffer, R.R., Frye, J. Journal of pharmaceutical sciences. (1985) [Pubmed]
  31. Preliminary studies of absorption and excretion of benoxaprofen in man. Smith, G.L., Goulbourn, R.A., Burt, R.A., Chatfield, D.H. British journal of clinical pharmacology. (1977) [Pubmed]
  32. Determination of benoxaprofen in plasma and urine by liquid chromatography. Ekman, L., Lindström, B., Nilsson, G., Wibell, L. J. Chromatogr. (1980) [Pubmed]
  33. Stereoselective inversion of (R)-(-)-benoxaprofen to the (S)-(+)-enantiomer in humans. Bopp, R.J., Nash, J.F., Ridolfo, A.S., Shepard, E.R. Drug Metab. Dispos. (1979) [Pubmed]
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