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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Tonotopic organization in the central auditory pathway of the Mongolian gerbil: a 2-deoxyglucose study.

The uptake of 2-deoxyglucose (2-DG) was employed to map functional activation of the central auditory pathway in the mongolian gerbil, during 85 dB SPL stimulation with pure tonal stimuli at frequencies of 0.75, 3.0, or 12.0 kHz. Pure tones produced foci of very high 2-DG uptake, when compared to adjacent tissue, in the cochlear nucleus, superior olivary complex, and inferior colliculus. Less distinct areas of elevated 2-DG uptake were seen in the dorsal and ventral nuclei of the lateral lemniscus, medial geniculate nucleus, and auditory cortex. Little or no change in the distribution of 2-DG uptake was noted in the nucleus of the trapezoid body. The location of discrete regions of relatively high 2-DG uptake varied systematically with stimulus frequency. The tonotopic organization demonstrated by 2-DG mapping agreed well with the results of previous electrophysiological studies for most structures. However, in the inferior colliculus, stimulus-evoked increases in 2-DG uptake were found to occur in a fixed pattern of three to four bands across the central nucleus, which did not correspond to any previously reported anatomical or physiological organization. Pure tonal stimuli activated discrete portions of this banding pattern. Also, a small area at the ventromedial edge of the colliculus was more broadly tuned than other regions of the nucleus. It is concluded that 2-DG uptake is well suited to the investigation of tonotopic organization. This technique reveals patterns of activation which have not been observed with other methodologies.[1]


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