Disease relevance of Inferior Colliculus

• Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis [1].
• This histological report verifies that deafness in Cockayne's syndrome is largely sensorineural and that degeneration of spiral ganglion in humans can lead to a chain of trans-synaptic degeneration in the ventral cochlear nucleus, medial dorsal olivary nucleus, and inferior colliculus [2].
• The effects of salicylate (a tinnitus inducer) were studied on the transient outward potassium current (I(K(A))) and the delayed rectifier potassium current (I(K(DR))) in acutely dissociated rat inferior colliculus neurons by the whole-cell voltage-clamp method [3].
• The P2Y purinoceptor-operated potassium channel is possibly regulated by the beta gamma subunits of a pertussis toxin-insensitive G-protein in cultured rat inferior colliculus neurons [4].
• In the inferior colliculus, adeno-associated virus (AAV) vectors are capable of gene transfer and stable, long-term expression, but it remained to be shown if this in vivo gene transfer could alter focal seizure sensitivity in the inferior colliculus [5].

Psychiatry related information on Inferior Colliculus

• These results suggest that GABA normally lengthens response latencies and creates a dorsoventral grading of delays in the inferior colliculus [6].
• Classical conditioning enhances auditory 2-deoxyglucose patterns in the inferior colliculus [7].
• Flight reactions to nitric oxide in the inferior colliculus of rats depend on NMDA receptor activation [8].
• It is important to know if the transmission of sound signals through the inferior colliculus is mediated by the transmitters glutamate or aspartate because of pharmacological consequences for auditory perception [9].

High impact information on Inferior Colliculus

• Newly learned auditory responses mediated by NMDA receptors in the owl inferior colliculus [10].
• The application of antagonists of the inhibitory neurotransmitters gamma-aminobutyric acid or glycine to neurons in the inferior colliculus eliminated duration tuning [11].
• Here we use Receiver Operating Characteristic analysis to compute neuronal Delta ITD thresholds from 53 cells in the inferior colliculus in guinea pigs [12].
• Moreover, only minor developmental defects were previously observed at the midline of the inferior colliculus and anterior cerebellum in mice that were homozygous for a targeted Pax5 mutation [13].
• In situ hybridization indicates Sm51 RNA is expressed throughout neuronal structures within rat brain, including the inferior colliculus, which does not possess the machinery to generate CGRP [14].

Chemical compound and disease context of Inferior Colliculus

• Responses of single nerve fibers to acoustic stimuli were recorded from the brachium of the inferior colliculus (BIC) using tungsten wire microelectrodes, and their response latencies and best amplitudes were measured [15].
• The contributions of the auditory thalamo-cortical pathway, mesencephalic reticular formation, and inferior colliculus to the surface recorded auditory middle latency response (MLR) were assessed by selective inactivation of these areas with lidocaine [16].
• GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma [17].
• Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis [18].
• The data suggest that carboplatin induced oxidative injury specifically in the inferior colliculus of the rat leading to hearing loss [19].

Biological context of Inferior Colliculus

• Single-unit action potentials were recorded from the inferior colliculus before and after local injection of the excitatory amino acid antagonist kynurenic acid into the DNLL [20].
• Gene expression changes in thalamus and inferior colliculus associated with inflammation, cellular stress, metabolism and structural damage in thiamine deficiency [21].
• It remains to be determined whether noise trauma-induced changes in glutamate decarboxylase levels in the inferior colliculus reflect protective up-regulation in response to intense stimulation, followed by the establishment of new neurotransmitter equilibrium levels [22].
• In contrast, neurons in the central nucleus of the inferior colliculus contain large amounts of GluR-B flip subunits resulting in Ca(2+) impermeable AMPA receptors with slow kinetics [23].
• To characterize further the pharmacology of the GABAA receptor in the inferior colliculus, GABA modulation of the picrotoxin binding site was examined using [3H]t-butylbicycloorthobenzoate [24].

Anatomical context of Inferior Colliculus

• The hierarchical neuronal network, subserving AGS in rodents is initiated in inferior colliculus (IC) and progresses to deep layers of superior colliculus (DLSC), pontine reticular formation (PRF) and periaqueductal gray (PAG) in genetic and ethanol withdrawal-induced AGS [25].
• Halothane anesthesia (1.5% inspired) caused few changes in local glucose metabolism, the most notable being decreased LCGU among structures of the auditory system (cochlear nucleus, lateral lemniscus, inferior colliculus) and increased LCGU in the interpeduncular nucleus [26].
• For example, in the auditory system, IGF-I mRNA is abundant in the cochlear nucleus, superior olive, lateral lemniscus, medial geniculate body, and inferior colliculus [27].
• One dose of thiamine replenishment at this stage transiently raised the pH in the inferior colliculus to 7.25 +/- 0.19 and in the medial dorsal nucleus to 7.20 +/- 0.13 (p less than 0.01) [28].
• Cellular colocalization of IDX1/IPF1 and somatostatin was found in several areas of the developing brain, including cortex, ganglionic eminence, hypothalamus, and inferior colliculus [29].

Associations of Inferior Colliculus with chemical compounds

• The cat inferior colliculus (IC) was studied with 2-deoxyglucose (2-DG) [30].
• NMDA and non-NMDA glutamate receptors in auditory transmission in the barn owl inferior colliculus [31].
• In contrast, no effect was seen in the inferior colliculus ipsilateral to the kynurenic acid injection [32].
• Ultrastructural analyses demonstrated that biocytin-labeled regenerating fibers established de novo synaptic profiles in the contralateral lobe of the inferior colliculus [33].
• Coronal brain slices from 21-50-d-old hooded rats were used to characterize intracellular responses of cells in both the external and dorsal cortices of the inferior colliculus (IC) [34].

Gene context of Inferior Colliculus

• This study examines calbindin D-28k and calretinin immunoreactivity in the inferior colliculus (IC) of young and old mice of two strains [35].
• Age-related changes in calbindin D-28k and calretinin immunoreactivity in the inferior colliculus of CBA/CaJ and C57Bl/6 mice [35].
• The torus semicircularis-the inferior colliculus homolog-expressed Otx2 in its ventricular lining exclusively, but it never expressed Pax2 [36].
• In contrast, CR immunoreactivity was already strong two days before birth, yet the number and intensity of labeled neurons subsequently decreased and CR disappeared almost completely in the superior olivary complex, nuclei of the lateral lemniscus, and central aspects of the inferior colliculus [37].
• In the adult, BDNF heavily labeled most neurons of the superior olivary nuclei and moderately labeled neurons of the inferior colliculus (IC) [38].

Analytical, diagnostic and therapeutic context of Inferior Colliculus

• Quantitative receptor autoradiography was used to assess GABAB receptor binding in three primary subdivisions of the inferior colliculus (IC): dorsal cortex (DCIC), external cortex (ECIC), and the central nucleus (CIC) of 3-, 18-20-, and 26-month-old Fischer 344 rats [39].
• Recently, we have shown that microinjections of NMDA into the inferior colliculus mimic these aversive effects and that the neural substrates responsible for learned escape behavior in the inferior colliculus are regulated by GABA-benzodiazepine mechanisms [40].
• The frequency organization in the inferior colliculus of neonatally-deafened rats was investigated using electrical stimulation of the cochlea and immunoreactivity for Fos as a marker of neuronal activity [41].
• Fine structure of GABA-labeled axonal endings in the inferior colliculus of the cat: immunocytochemistry on deplasticized ultrathin sections [42].
• N-Methyl-D-aspartate (NMDA) (10 to 20 nmol) or bicuculline (15 to 50 pmol) in 0.5 microliter was infused bilaterally into the inferior colliculus or the deep layers of superior colliculus (DLSC) in normal rats, and the response to high intensity acoustic stimulation was examined [43].

References