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MeSH Review

Auditory Pathways

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Disease relevance of Auditory Pathways


High impact information on Auditory Pathways

  • At the endbulb of Held, a fast central calyceal synapse in the auditory pathway, cyclothiazide (CTZ) abolished marked paired pulse depression (PPD) by acting presynaptically to enhance transmitter release, rather than by blocking postsynaptic receptor desensitization [3].
  • Eight autistic children (and no control subjects) had ABR transmission time values 3 SDs beyond the normal mean, suggesting auditory processing defects peripheral to or within the brainstem auditory pathway [4].
  • KCNQ4 is also expressed in neurons of many, but not all, nuclei of the central auditory pathway, and is absent from most other brain regions [5].
  • D2 mRNA concentration was increased severalfold over normal levels in relay nuclei and cortical targets of the primary somatosensory and auditory pathways [6].
  • Thus, the ability of 5-HT to modulate glutamatergic activity in auditory pathways to the amygdala is dependent on the presence of CORT and possibly glucocorticoid activation [7].

Biological context of Auditory Pathways


Anatomical context of Auditory Pathways

  • KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway [5].
  • In the barn owl, calbindin-like immunoreactivity was found to be selectively present in brain stem auditory pathways used to process interaural time differences, but was absent from the interaural intensity pathway [13].
  • Visual projections induced into the auditory pathway of ferrets. I. Novel inputs to primary auditory cortex (AI) from the LP/pulvinar complex and the topography of the MGN-AI projection [14].
  • Because the changes that occurred in group D involved all four major waves, it is not possible to separate out a toxic effect of bilirubin, localized to the auditory nerve and the auditory pathway, from a generalized systemic effect which could cause attenuation of the entire response [15].
  • Seven essentially healthy term infants who received gentamicin starting on the 1st day of life for prolonged rupture of membranes and maternal fever were compared with nine healthy term infants to determine whether this drug induces alterations in the auditory pathway [16].

Associations of Auditory Pathways with chemical compounds


Gene context of Auditory Pathways

  • These results are consistent with the pattern of expression of PMP22 in the peripheral portion of the eighth nerve (myelinated by Schwann cells) and of connexin32 in the central portion in the brainstem auditory pathways (myelinated by oligodendrocytes) [21].
  • Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway [22].
  • In the present study, FGF-2 immunoreactivity was analyzed in the auditory pathways of the adult rat, employing a well-characterized polyclonal antibody against FGF-2 [23].
  • The presence of 5-HTT-IR in neurons located in the VCN indicates a regional expression of the 5-HTT that is related to the ascending auditory pathway [24].
  • Anti-aromatase, but not anti-AR, labeled fiber tracts and fibrous layers in visual and auditory pathways, and perikarya and processes of premotor neurons known to integrate sensory input (reticulospinal neurons, Mauthner cells) [25].

Analytical, diagnostic and therapeutic context of Auditory Pathways


  1. Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness. Cediel, R., Riquelme, R., Contreras, J., Díaz, A., Varela-Nieto, I. Eur. J. Neurosci. (2006) [Pubmed]
  2. Electric response audiometry in infants and preschool children. Long-term control of the results. Garrubba, V., Grandori, F., Lamoretti, M., Nicolai, P., Zanetti, D., Antonelli, A.R. Acta oto-laryngologica. Supplementum. (1991) [Pubmed]
  3. A novel presynaptic inhibitory mechanism underlies paired pulse depression at a fast central synapse. Bellingham, M.C., Walmsley, B. Neuron (1999) [Pubmed]
  4. Auditory brainstem evoked responses in autistic children. Tanguay, P.E., Edwards, R.M., Buchwald, J., Schwafel, J., Allen, V. Arch. Gen. Psychiatry (1982) [Pubmed]
  5. KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway. Kharkovets, T., Hardelin, J.P., Safieddine, S., Schweizer, M., El-Amraoui, A., Petit, C., Jentsch, T.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. Guadaño-Ferraz, A., Escámez, M.J., Rausell, E., Bernal, J. J. Neurosci. (1999) [Pubmed]
  7. Serotonin modulation of sensory inputs to the lateral amygdala: dependency on corticosterone. Stutzmann, G.E., McEwen, B.S., LeDoux, J.E. J. Neurosci. (1998) [Pubmed]
  8. Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function. Knipper, M., Bandtlow, C., Gestwa, L., Köpschall, I., Rohbock, K., Wiechers, B., Zenner, H.P., Zimmermann, U. Development (1998) [Pubmed]
  9. Effects of halothane or enflurane with controlled ventilation on auditory evoked potentials. Thornton, C., Heneghan, C.P., James, M.F., Jones, J.G. British journal of anaesthesia. (1984) [Pubmed]
  10. Effects of sodium pentobarbital, ketamine, halothane, and chloralose on brainstem auditory evoked responses. Cohen, M.S., Britt, R.H. Anesth. Analg. (1982) [Pubmed]
  11. Vasopressin and oxytocin do not influence early sensory processing but affect mood and activation in man. Pietrowsky, R., Braun, D., Fehm, H.L., Pauschinger, P., Born, J. Peptides (1991) [Pubmed]
  12. Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis. Szczepaniak, W.S., Møller, A.R. Hear. Res. (1996) [Pubmed]
  13. Differential calbindin-like immunoreactivity in the brain stem auditory system of the chinchilla. Kelley, P.E., Frisina, R.D., Zettel, M.L., Walton, J.P. J. Comp. Neurol. (1992) [Pubmed]
  14. Visual projections induced into the auditory pathway of ferrets. I. Novel inputs to primary auditory cortex (AI) from the LP/pulvinar complex and the topography of the MGN-AI projection. Pallas, S.L., Roe, A.W., Sur, M. J. Comp. Neurol. (1990) [Pubmed]
  15. Effect of bilirubin on brainstem auditory evoked potentials in the asphyxiated rat. Jirka, J.H., Duckrow, R.B., Kendig, J.W., Maisels, M.J. Pediatr. Res. (1985) [Pubmed]
  16. Effect of gentamicin on the auditory brainstem evoked response in term infants: a preliminary report. Kohelet, D., Usher, M., Arbel, E., Arlazoroff, A., Goldberg, M. Pediatr. Res. (1990) [Pubmed]
  17. Tonotopic organization in the central auditory pathway of the Mongolian gerbil: a 2-deoxyglucose study. Ryan, A.F., Woolf, N.K., Sharp, F.R. J. Comp. Neurol. (1982) [Pubmed]
  18. Glutamic acid decarboxylase-like immunoreactivity in brainstem auditory nuclei of the rat. Moore, J.K., Moore, R.Y. J. Comp. Neurol. (1987) [Pubmed]
  19. Distribution of GABAA, GABAB, and glycine receptors in the central auditory system of the big brown bat, Eptesicus fuscus. Fubara, B.M., Casseday, J.H., Covey, E., Schwartz-Bloom, R.D. J. Comp. Neurol. (1996) [Pubmed]
  20. Phasic activity induced by p-chlorophenylalanine in the auditory pathway. Ayala-Guerrero, F., Perera-Ortiz, Y., Vargas, L. Neuropharmacology (1981) [Pubmed]
  21. Slowing of central conduction in X-linked Charcot-Marie-Tooth neuropathy shown by brain stem auditory evoked responses. Nicholson, G., Corbett, A. J. Neurol. Neurosurg. Psychiatr. (1996) [Pubmed]
  22. Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway. Chambard, J.M., Ashmore, J.F. Pflugers Arch. (2005) [Pubmed]
  23. Fibroblast growth factor-2 immunoreactivity is present in the central and peripheral auditory pathways of adult rats. Silva, V.A., Gomide, V.C., Chadi, G. J. Morphol. (2005) [Pubmed]
  24. Postnatal expression of the serotonin transporter in auditory brainstem neurons. Thompson, A.M., Lauder, J.M. Dev. Neurosci. (2005) [Pubmed]
  25. Immunolocalization of aromatase- and androgen receptor-positive neurons in the goldfish brain. Gelinas, D., Callard, G.V. Gen. Comp. Endocrinol. (1997) [Pubmed]
  26. Lysosomal sulfatide storage in the brain of arylsulfatase A-deficient mice: cellular alterations and topographic distribution. Wittke, D., Hartmann, D., Gieselmann, V., Lüllmann-Rauch, R. Acta Neuropathol. (2004) [Pubmed]
  27. Acute study on the efficacy and safety of an auditory brainstem prosthesis. Liu, X., McPhee, G., Seldon, H.L., Clark, G.M. Acta Otolaryngol. (1998) [Pubmed]
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