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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.

Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.[1]

References

  1. Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation. Cheetham, B.F., Shaw, D.C., Bellett, A.J. Mol. Cell. Biol. (1982) [Pubmed]
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