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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration.

Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO2- to NO3- at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13NO3- to 13NO2- was observed. A mechanistic hypothesis invoking oxidation of 13NO2- by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO2- or nitrogen dioxide.[1]


  1. Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration. Parks, N.J., Krohn, K.J., Mathis, C.A., Chasko, J.H., Geiger, K.R., Gregor, M.E., Peek, N.F. Science (1981) [Pubmed]
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