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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fosfomycin kinetics after intravenous and oral administration to human volunteers.

The pharmacokinetics of fosfomycin, administered intravenously and orally at two different doses (20 and 40 mg/kg of body weight), was studied in seven volunteers. The elimination profile of this antibiotic, when administered intravenously, followed a two-compartment kinetic model, independent of dosage, giving an elimination half-life of 2.23 +/- 0.62 h and an average total volume of distribution at steady state of 0.34 liter/kg. Peak serum levels after rapid intravenous administration of 20 and 40 mg/kg were 132.1 +/- 31.8 and 259.3 +/- 32.5 micrograms/ml, respectively. Peak serum levels after oral administration were 7.1 +/- 1.6 and 9.4 +/- 3.6 micrograms/ml for the 20 and 40 mg/kg doses, respectively. During the first 24 h after administration, an average of 80% of the intravenous doses and less than 25% of the oral doses were recovered in the urine.[1]


  1. Fosfomycin kinetics after intravenous and oral administration to human volunteers. Goto, M., Sugiyama, M., Nakajima, S., Yamashina, H. Antimicrob. Agents Chemother. (1981) [Pubmed]
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