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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neutralization antibody responses induced by Japanese encephalitis virus vaccine.

Single doses of Japanese encephalitis (JE) vaccine of the Nakayama strain were given to members of the staffs of a hospital and 99 paired-sera were obtained. Neutralization antibody titers of the sera were determined against the Nakayama strain and E-50 strain, isolated from wild Culex tritaeniorhynchus using clone C6/36 of Singh's Aedes albopictus mosquito cell culture. Post-vaccination sera showed a significant neutralizing antibody response against both the Nakayama and E-50 strain. The geometrical mean neutralization titers of post-vaccination sera against the Nakayama and E-50 strains were in the same order, although the geometrical mean neutralization titer against the Nakayama strain was the higher in pre-vaccination sera. The antibody responses against the Nakayama strain and E-50 strain were somewhat different in detail: 7 individuals with a pre-vaccination neutralization titers of less than 10 showed antibody responses to the Nakayama strain, whereas 3 individuals of the same group did not show any detectable response to the E-50 strain.[1]


  1. Neutralization antibody responses induced by Japanese encephalitis virus vaccine. Susilowati, S., Okuno, Y., Fukunaga, T., Tadano, M., Juang, R.F., Fukai, K. Biken journal. (1981) [Pubmed]
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