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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tumor promoter TPA mimics irradiation effects on the cell cycle of HeLa cells.

When asynchronous and synchronous HeLa cells were incubated with small doses (10(-7) M) of tumor promoter 12 O-tetradecanoylphorbol-13-acetate (TPA), a variety of transient alterations in the replication cycle were detected within 24 hours by the use of independent methods. Especially, a delayed passage through the S phase and influences on the G2 phase resemble x-ray irradiation effects on cell cultures. None of these alterations was observed with the hyperplasiogenic but nonpromoting 4-O-methyl-TPA.[1]

References

  1. Tumor promoter TPA mimics irradiation effects on the cell cycle of HeLa cells. Kinzel, V., Richards, J., Stöhr, M. Science (1980) [Pubmed]
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