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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Tetracycline transport in Bacteroides fragilis.

In susceptible strain of Bacteroides fragilis, tetracycline uptake is biphasic. The initial phase is independent of adenosine 5'-triphosphate synthesis, which is coupled to fumarate reduction; this phase is not altered by expression of tetracycline resistance genes in a resistant strain. The second phase appears to occur by active transport, since it is largely reduced by rotenone, an inhibitor of electron transport to fumarate; moreover, this phase is under negative control of the tetracycline resistance gene.[1]


  1. Tetracycline transport in Bacteroides fragilis. Fayolle, F., Privitera, G., Sebald, M. Antimicrob. Agents Chemother. (1980) [Pubmed]
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