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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

p-Chlorophenylalanine damages pancreatic acinar cell of the chicken.

1. Birds were injected intraperitoneally with DL-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment. The weight and cell size of pancreas increased by the p-CP treatment. 2. The application of acetylcholine (5.50 x 10(-9) to 5.50 x 10(-5) M) caused a dose dependent increase in amylase release from the superfused segment of pancreas, although the response significantly decreased in the pancreatic segment treated with p-CP, compared with the control.[1]


  1. p-Chlorophenylalanine damages pancreatic acinar cell of the chicken. Furuse, M., Satoh, S., Yang, S.I., Watanabe, T., Okumura, J. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1993) [Pubmed]
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