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Chemical Compound Review

Fenclonin     2-amino-3-(4- chlorophenyl)propanoic acid

Synonyms: Fenclonina, Fenclonine, Fenchlonine, Fencloninum, DL-PCPA, ...
 
 
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Disease relevance of p-chlorophenylalanine

 

Psychiatry related information on p-chlorophenylalanine

 

High impact information on p-chlorophenylalanine

 

Chemical compound and disease context of p-chlorophenylalanine

 

Biological context of p-chlorophenylalanine

 

Anatomical context of p-chlorophenylalanine

 

Associations of p-chlorophenylalanine with other chemical compounds

 

Gene context of p-chlorophenylalanine

  • Pretreatment with p-chlorophenylalanine had no effect on the PRL secretory responses to DOM given at 0300 or 1200 h, but it attenuated the augmented PRL secretory response at 1700 h [32].
  • Impairment of the serotonergic transmission by blockade of 5-HT synthesis using p-chlorophenylalanine, as well as attenuation of the noradrenergic transmission by NA depletion from terminals by DSP4, did not significantly change NPY mRNA expression or the mean number of NPY-immunoreactive neurons in the amygdala [33].
  • The present study demonstrates that TPH is inhibited by a novel compound, p-ethynylphenylalanine (pEPA), produced by the Heck reaction of trimethylsilylacetylene with N-tertbutyloxycarbonyl-4-iodo-L-phenylalanine methyl ester. pEPA is a more potent and specific inhibitor of TPH than p-chlorophenylalanine (pCPA) [34].
  • The increase in Arc expression induced by paroxetine/WAY 100635 was abolished by the 5-HT synthesis inhibitor, p-chlorophenylalanine (300 mg/kg i.p., daily for two days) [35].
  • The 5-HT1A receptors mediating the corticosterone secretion appear to be postsynaptic to the 5-HT neurons, since the response to 8-OH-DPAT was not decreased but potentiated by depletion of 5-HT with p-chlorophenylalanine pretreatment of the animals [36].
 

Analytical, diagnostic and therapeutic context of p-chlorophenylalanine

References

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  12. The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis. Ballinger, A., El-Haj, T., Perrett, D., Turvill, J., Obeid, O., Dryden, S., Williams, G., Farthing, M.J. Gastroenterology (2000) [Pubmed]
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  17. Stereospecific actions of 2,5-dimethoxy-4-methylamphetamine (DOM) on colonic temperature in the rat at various ambient temperatures. Beaton, J.M., Benington, F., Bradley, R.J., Kuhlemeier, K.V., Morin, R.D. Br. J. Pharmacol. (1976) [Pubmed]
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  22. [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. Dewar, K.M., Grondin, L., Carli, M., Lima, L., Reader, T.A. J. Neurochem. (1992) [Pubmed]
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  24. p-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product. Rattray, M., Baldessari, S., Gobbi, M., Mennini, T., Samanin, R., Bendotti, C. J. Neurochem. (1996) [Pubmed]
  25. Ultrastructural changes in rat optic nerve associated with hyperphenylalaninemia induced by para-chlorophenylalanine and phenylalanine. Avins, L., Guroff, G., Kuwabara, T. J. Neuropathol. Exp. Neurol. (1975) [Pubmed]
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  29. Heterogeneity of cortical and hippocampal 5-HT1A receptors: a reappraisal of homogenate binding with 8-[3H]hydroxydipropylaminotetralin. Nénonéné, E.K., Radja, F., Carli, M., Grondin, L., Reader, T.A. J. Neurochem. (1994) [Pubmed]
  30. The influence of raphe lesions, p-chlorophenylalanine, and ketanserin on the estrogen-induced afternoon prolactin surge. Pan, J.T., Gala, R.R. Endocrinology (1987) [Pubmed]
  31. A serotonergic mechanism of the prolactin-stimulating action of metoclopramide. Fang, V.S., Shian, L.R. Endocrinology (1981) [Pubmed]
  32. Hypothalamic factors involved in the endogenous stimulatory rhythm regulating prolactin secretion. Arey, B.J., Freeman, M.E. Endocrinology (1989) [Pubmed]
  33. Pharmacological studies on the monoaminergic influence on the synthesis and expression of neuropeptide Y and corticotropin releasing factor in rat brain amygdala. Smiałowska, M., Bajkowska, M., Heilig, M., Obuchowicz, E., Turchan, J., Maj, M., Przewłocki, R. Neuropeptides (2001) [Pubmed]
  34. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. Stokes, A.H., Xu, Y., Daunais, J.A., Tamir, H., Gershon, M.D., Butkerait, P., Kayser, B., Altman, J., Beck, W., Vrana, K.E. J. Neurochem. (2000) [Pubmed]
  35. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Castro, E., Tordera, R.M., Hughes, Z.A., Pei, Q., Sharp, T. J. Neurochem. (2003) [Pubmed]
  36. Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist. Kelder, D., Ross, S.B. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  37. Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Botney, M., Fields, H.L. Ann. Neurol. (1983) [Pubmed]
  38. p-chlorophenylalanine increases tryptophan-5-hydroxylase mRNA levels in the rat dorsal raphe: a time course study using in situ hybridization. Cortés, R., Mengod, G., Celada, P., Artigas, F. J. Neurochem. (1993) [Pubmed]
  39. Met-enkephalin-Arg6-Phe7 in spinal cord and brain following traumatic injury to the spinal cord: influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique. Sharma, H.S., Nyberg, F., Thörnwall, M., Olsson, Y. Neuropharmacology (1993) [Pubmed]
  40. Reinitiation of ovulatory cycles in incubating female turkeys by an inhibitor of serotonin synthesis, P-chlorophenylalanine. El Halawani, M.E., Silsby, J.L., Fehrer, S.C., Behnke, E.J. Biol. Reprod. (1983) [Pubmed]
 
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