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Chemical Compound Review

Fenclonin     2-amino-3-(4- chlorophenyl)propanoic acid

Synonyms: Fenclonina, Fenclonine, Fenchlonine, Fencloninum, DL-PCPA, ...
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Disease relevance of p-chlorophenylalanine


Psychiatry related information on p-chlorophenylalanine


High impact information on p-chlorophenylalanine


Chemical compound and disease context of p-chlorophenylalanine


Biological context of p-chlorophenylalanine


Anatomical context of p-chlorophenylalanine


Associations of p-chlorophenylalanine with other chemical compounds


Gene context of p-chlorophenylalanine

  • Pretreatment with p-chlorophenylalanine had no effect on the PRL secretory responses to DOM given at 0300 or 1200 h, but it attenuated the augmented PRL secretory response at 1700 h [32].
  • Impairment of the serotonergic transmission by blockade of 5-HT synthesis using p-chlorophenylalanine, as well as attenuation of the noradrenergic transmission by NA depletion from terminals by DSP4, did not significantly change NPY mRNA expression or the mean number of NPY-immunoreactive neurons in the amygdala [33].
  • The present study demonstrates that TPH is inhibited by a novel compound, p-ethynylphenylalanine (pEPA), produced by the Heck reaction of trimethylsilylacetylene with N-tertbutyloxycarbonyl-4-iodo-L-phenylalanine methyl ester. pEPA is a more potent and specific inhibitor of TPH than p-chlorophenylalanine (pCPA) [34].
  • The increase in Arc expression induced by paroxetine/WAY 100635 was abolished by the 5-HT synthesis inhibitor, p-chlorophenylalanine (300 mg/kg i.p., daily for two days) [35].
  • The 5-HT1A receptors mediating the corticosterone secretion appear to be postsynaptic to the 5-HT neurons, since the response to 8-OH-DPAT was not decreased but potentiated by depletion of 5-HT with p-chlorophenylalanine pretreatment of the animals [36].

Analytical, diagnostic and therapeutic context of p-chlorophenylalanine


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  2. Trans-synaptic modulation via muscarinic receptors of serotonin-containing small intensely fluorescent cells of superior cervical ganglion. Hadjiconstantinou, M., Potter, P.E., Neff, N.H. J. Neurosci. (1982) [Pubmed]
  3. p-Chlorphenylalanine effect on phenylalanine hydroxylase in hepatoma cells in culture. Miller, M.R., McClure, D., Shiman, R. J. Biol. Chem. (1975) [Pubmed]
  4. Independent regulation of neuropeptide mRNA level and poly(A) tail length. Carter, D.A., Murphy, D. J. Biol. Chem. (1989) [Pubmed]
  5. Effects of dietary mixtures of amino acids on fetal growth and maternal and fetal amino acid pools in experimental maternal phenylketonuria. Austic, R.E., Su, C.L., Strupp, B.J., Levitsky, D.A. Am. J. Clin. Nutr. (1999) [Pubmed]
  6. Sleep regulation after reduction of brain serotonin: effect of p-chlorophenylalanine combined with sleep deprivation in the rat. Tobler, I., Borbély, A.A. Sleep. (1982) [Pubmed]
  7. Differential effects of para-chlorophenylalanine on self-stimulation in caudate-putamen and lateral hypothalamus. Phillips, A.G., Carter, D.A., Fibiger, H.C. Psychopharmacology (Berl.) (1976) [Pubmed]
  8. Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan. Denoyer, M., Sallanon, M., Kitahama, K., Aubert, C., Jouvet, M. Neuroscience (1989) [Pubmed]
  9. The failure of p-chlorophenylalanine to affect voluntary alcohol consumption in rats. Holman, R.B., Hoyland, V., Shillito, E.E. Br. J. Pharmacol. (1975) [Pubmed]
  10. Stereotypy and hyperactivity in rats receiving ethanol and a monoamine oxidase inhibitor. Holman, R.B., Elliott, G.R., Kramer, A.M., Seagraves, E., Barchas, J.D. Psychopharmacology (Berl.) (1977) [Pubmed]
  11. Different synaptic location of mianserin and imipramine binding sites. Brunello, N., Chuang, D.M., Costa, E. Science (1982) [Pubmed]
  12. The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis. Ballinger, A., El-Haj, T., Perrett, D., Turvill, J., Obeid, O., Dryden, S., Williams, G., Farthing, M.J. Gastroenterology (2000) [Pubmed]
  13. Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Esaki, T., Cook, M., Shimoji, K., Murphy, D.L., Sokoloff, L., Holmes, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone. Zarandi, M., Horvath, J.E., Halmos, G., Pinski, J., Nagy, A., Groot, K., Rekasi, Z., Schally, A.V. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  15. Effects of p-chlorophenylalanine and alpha-methylphenylalanine on amino acid uptake and protein synthesis in mouse neuroblastoma cells. Kelly, C.J., Johnson, T.C. Biochem. J. (1978) [Pubmed]
  16. Effects of brain serotonin alterations on prostaglandin E1-induced bradycardia in rats. Lin, M.T. J. Pharmacol. Exp. Ther. (1979) [Pubmed]
  17. Stereospecific actions of 2,5-dimethoxy-4-methylamphetamine (DOM) on colonic temperature in the rat at various ambient temperatures. Beaton, J.M., Benington, F., Bradley, R.J., Kuhlemeier, K.V., Morin, R.D. Br. J. Pharmacol. (1976) [Pubmed]
  18. Possible neuronal mechanisms involved in neurotensin-induced catalepsy in mice. Shibata, K., Yamada, K., Furukawa, T. Psychopharmacology (Berl.) (1987) [Pubmed]
  19. Possible involvement of 5-HT2 receptor activation in aggravation of diet-induced acute pancreatitis in mice. Yoshino, T., Yamaguchi, I. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  20. Systemic administration of beta-endorphin: potent hypotensive effect involving a serotonergic pathway. Lemaire, I., Tseng, R., Lemaire, S. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  21. In vivo tyrosine hydroxylation in rat retina: effect of aspartame ingestion in rats pretreated with p-chlorophenylalanine. Fernstrom, J.D., Fernstrom, M.H., Massoudi, M.S. Am. J. Clin. Nutr. (1991) [Pubmed]
  22. [3H]paroxetine binding and serotonin content of rat cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region following p-chlorophenylalanine and p-chloroamphetamine treatment. Dewar, K.M., Grondin, L., Carli, M., Lima, L., Reader, T.A. J. Neurochem. (1992) [Pubmed]
  23. A dissociation between temperature regulation and fever in the rabbit. Borsook, D., Laburn, H.P., Rosendorff, C., Willies, G.H., Woolf, C.J. J. Physiol. (Lond.) (1977) [Pubmed]
  24. p-Chlorphenylalanine changes serotonin transporter mRNA levels and expression of the gene product. Rattray, M., Baldessari, S., Gobbi, M., Mennini, T., Samanin, R., Bendotti, C. J. Neurochem. (1996) [Pubmed]
  25. Ultrastructural changes in rat optic nerve associated with hyperphenylalaninemia induced by para-chlorophenylalanine and phenylalanine. Avins, L., Guroff, G., Kuwabara, T. J. Neuropathol. Exp. Neurol. (1975) [Pubmed]
  26. p-Chlorophenylalanine-induced alteration of somatodendritic levels of tryptophan hydroxylase within the rat mesencephalic raphe nuclei. Raison, S., Rousset, C., Pujol, J.F., Weissmann, D. J. Neurochem. (1996) [Pubmed]
  27. Alteration of substance P after trauma to the spinal cord: an experimental study in the rat. Sharma, H.S., Nyberg, F., Olsson, Y., Dey, P.K. Neuroscience (1990) [Pubmed]
  28. Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition. Ugedo, L., Grenhoff, J., Svensson, T.H. Psychopharmacology (Berl.) (1989) [Pubmed]
  29. Heterogeneity of cortical and hippocampal 5-HT1A receptors: a reappraisal of homogenate binding with 8-[3H]hydroxydipropylaminotetralin. Nénonéné, E.K., Radja, F., Carli, M., Grondin, L., Reader, T.A. J. Neurochem. (1994) [Pubmed]
  30. The influence of raphe lesions, p-chlorophenylalanine, and ketanserin on the estrogen-induced afternoon prolactin surge. Pan, J.T., Gala, R.R. Endocrinology (1987) [Pubmed]
  31. A serotonergic mechanism of the prolactin-stimulating action of metoclopramide. Fang, V.S., Shian, L.R. Endocrinology (1981) [Pubmed]
  32. Hypothalamic factors involved in the endogenous stimulatory rhythm regulating prolactin secretion. Arey, B.J., Freeman, M.E. Endocrinology (1989) [Pubmed]
  33. Pharmacological studies on the monoaminergic influence on the synthesis and expression of neuropeptide Y and corticotropin releasing factor in rat brain amygdala. Smiałowska, M., Bajkowska, M., Heilig, M., Obuchowicz, E., Turchan, J., Maj, M., Przewłocki, R. Neuropeptides (2001) [Pubmed]
  34. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. Stokes, A.H., Xu, Y., Daunais, J.A., Tamir, H., Gershon, M.D., Butkerait, P., Kayser, B., Altman, J., Beck, W., Vrana, K.E. J. Neurochem. (2000) [Pubmed]
  35. Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration. Castro, E., Tordera, R.M., Hughes, Z.A., Pei, Q., Sharp, T. J. Neurochem. (2003) [Pubmed]
  36. Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist. Kelder, D., Ross, S.B. Naunyn Schmiedebergs Arch. Pharmacol. (1992) [Pubmed]
  37. Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Botney, M., Fields, H.L. Ann. Neurol. (1983) [Pubmed]
  38. p-chlorophenylalanine increases tryptophan-5-hydroxylase mRNA levels in the rat dorsal raphe: a time course study using in situ hybridization. Cortés, R., Mengod, G., Celada, P., Artigas, F. J. Neurochem. (1993) [Pubmed]
  39. Met-enkephalin-Arg6-Phe7 in spinal cord and brain following traumatic injury to the spinal cord: influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique. Sharma, H.S., Nyberg, F., Thörnwall, M., Olsson, Y. Neuropharmacology (1993) [Pubmed]
  40. Reinitiation of ovulatory cycles in incubating female turkeys by an inhibitor of serotonin synthesis, P-chlorophenylalanine. El Halawani, M.E., Silsby, J.L., Fehrer, S.C., Behnke, E.J. Biol. Reprod. (1983) [Pubmed]
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