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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Relationship between Ricinus communis agglutinin-1 binding and nucleolar organizer regions in human gliomas.

Histochemical staining using lectins from Ricinus communis ( RCA-1), Arachis hypogaea, and Canavalia ensiformis was investigated in 40 human gliomas, three central neurocytomas, one human neuroblastoma cell line (IMR-32), and two normal brain tissues. Staining was uniform in low-grade gliomas, but heterogeneous in high-grade gliomas, particularly with RCA-1. The correlation between RCA-1 reactivity and cellular proliferative potential was investigated in 10 high-grade gliomas using a combined staining technique: the silver colloid method for nucleolar organizer regions (Ag-NORs) and histochemistry with RCA-1. The mean number of Ag-NORs counted on a simple preparation was significantly greater in the nuclei of RCA-1-negative cells than in those of RCA-1-positive cells (p < 0.001). The staining intensity of inflammatory cells was obviously higher than that of neoplastic cells, and therefore inflammatory cells were easily discriminated from neoplastic cells. Combined RCA-1 histochemical and Ag-NOR silver colloid staining revealed heterogeneous expression of RCA-1 receptor in high-grade gliomas with changes in Ag-NOR number. This result seems to show that high-grade gliomas express heterogeneous cellular carbohydrate structure and proliferative potential even within the same tumor.[1]


  1. Relationship between Ricinus communis agglutinin-1 binding and nucleolar organizer regions in human gliomas. Niikawa, S., Hara, A., Shirakami, S., Zhang, W., Sakai, N., Yamada, H., Shimokawa, K. Neurol. Med. Chir. (Tokyo) (1993) [Pubmed]
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