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MeSH Review


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Disease relevance of Canavalia


High impact information on Canavalia


Chemical compound and disease context of Canavalia


Biological context of Canavalia


Anatomical context of Canavalia


Associations of Canavalia with chemical compounds

  • A convenient method of preparation of high-activity urease from Canavalia ensiformis by covalent chromatography and an investigation of its thiol groups with 2,2'-dipyridyl disulphide as a thiol titrant and reactivity probe [20].
  • Maturation events have been studied in developing jackbean (Canavalia ensiformis) cotyledons by using a combination of analysis by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis, overlays with 125I-concanavalin A (Con A) and the use of anti-(Con A) after Western transfer [21].
  • The mannose-carrying amphiphiles incorporated in liposomes were recognized by a lectin from Canavalia ensiformis (Con A), which was proven by the increase in turbidity of the liposome suspension after mixing with Con A [22].
  • These data indicate that, although canavanine is not the principal antinutritional factor in Canavalia ensiformis seeds, its presence in the diet precludes optimum performance of chicks [23].
  • Canavalia ensiformis agglutinin, Glycine max agglutinin and Triticum vulgaris agglutinin were potent inhibitors of virus binding [24].

Gene context of Canavalia

  • The earliest changes detectable within these areas of brain in the younger patients involved a fine diffuse deposition of amyloid (A4) protein and a uniform granular accumulation of an oligosaccharide recognized by the lectin from Canavalia ensiformis (ConA) [25].
  • The immunoscreening method was used to isolate cDNAs of 1323 bp (ClOCT1) and 1433 bp (ClOCT2) encoding two ornithine carbamoyltransferases (OCT, EC from the cDNA expression library of Canavalia lineata leaves constructed in a lambdaZAP Express vector [26].
  • The majority of surface polypeptides, ranging in relative molecular masses from 27 to 113 kDa, reacted with horseradish peroxidase-labelled Canavalia ensiformis (Con A), Erythrina corallodendron (ECA), Glycine max (SBA) and Triticum vulgaris (WGA) lectins indicating that most, if not all, tegumental proteins are glycosylated [27].
  • A new ent-kaurane-type glycoside, canavalioside, and eight new acylated flavonol glycosides, gladiatosides A1, A2, A3, B1, B2, B3, C1, and C2, were isolated from the seed of Canavalia gladiata together with robinin, kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside, and kaikasaponin III [28].
  • A lectin from Japanese jack bean (Canavalia gladiata agglutinin, CGA) was purified by affinity chromatography on a maltamyl-Sepharose column [29].

Analytical, diagnostic and therapeutic context of Canavalia

  • The maturation of the lectin concanavalin A from the jack bean, Canavalia ensiformis, involves an unusual post-translational cleavage at three internal asparagine residues and the subsequent rearrangement and ligation of two of the resulting fragments [30].
  • Two subtilisin inhibitors (CLSI-II and -III) were purified from seeds of Canavalia lineata by extraction with water, ammonium sulfate precipitation, and chromatographies on DEAE-Toyopearl and hydroxyapatite [31].
  • Three major serine proteinase inhibitors (SBI-1, -2, and -3) were purified from the seeds of white sword bean (Canavalia gladiata) by FPLC and reversed-phase HPLC [32].
  • The reflex tear glycoproteins were analyzed by lectin affinity associated electrotransfer of SDS-PAGE with a panel of five biotinylated lectin probes: Canavalia ensiformis (Con A), Artocarpus integrifolia (Jacalin), glycine max (SBA), Ulex europaeus (UEA 1), and Triticum vulgaris (WGA) agglutinins [33].


  1. Lectin expression in carcinoid tumours of the gastrointestinal tract. Raju, G.C., Lee, Y.S. J. Pathol. (1988) [Pubmed]
  2. Further studies on the hypoxia produced by canatoxin in rats. Ribeiro-DaSilva, G., Prado, J.F., Collares, C.B., Siste-Campos, M. Braz. J. Med. Biol. Res. (1992) [Pubmed]
  3. Isolation and characterization of the catalase gene from Rhizobium sp. SNU003, a root nodule symbiont of Canavalia lineata. Kwon, S.I., An, C.S. Mol. Cells (1999) [Pubmed]
  4. Relationship between Ricinus communis agglutinin-1 binding and nucleolar organizer regions in human gliomas. Niikawa, S., Hara, A., Shirakami, S., Zhang, W., Sakai, N., Yamada, H., Shimokawa, K. Neurol. Med. Chir. (Tokyo) (1993) [Pubmed]
  5. Purification and characterization of the higher plant enzyme L-canaline reductase. Rosenthal, G.A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite L-canavanine. Swaffar, D.S., Ang, C.Y., Desai, P.B., Rosenthal, G.A. Cancer Res. (1994) [Pubmed]
  7. Asparaginyl endopeptidase of jack bean seeds. Purification, characterization, and high utility in protein sequence analysis. Abe, Y., Shirane, K., Yokosawa, H., Matsushita, H., Mitta, M., Kato, I., Ishii, S. J. Biol. Chem. (1993) [Pubmed]
  8. Evidence of altered structural and secretory glycoconjugates in the jejunal mucosa of patients with gluten sensitive enteropathy and subtotal villous atrophy. Vecchi, M., Torgano, G., de Franchis, R., Tronconi, S., Agape, D., Ronchi, G. Gut (1989) [Pubmed]
  9. Crystal structure of concanavalin B at 1.65 A resolution. An "inactivated" chitinase from seeds of Canavalia ensiformis. Hennig, M., Jansonius, J.N., Terwisscha van Scheltinga, A.C., Dijkstra, B.W., Schlesier, B. J. Mol. Biol. (1995) [Pubmed]
  10. Convulsions induced by canatoxin in rats are probably a consequence of hypoxia. Ribeiro-DaSilva, G., Pires-Barbosa, R., Prado, J.F., Carlini, C.R. Braz. J. Med. Biol. Res. (1989) [Pubmed]
  11. Two genes for the high mobility group protein HMG-Y are present in the genome of Canavalia gladiata D.C. Yamamoto, S., Minamikawa, T. Plant Mol. Biol. (1997) [Pubmed]
  12. Changes of lectin staining pattern of the Golgi stack during differentiation of the ameloblast in developing rat molar tooth germs. Matsuo, S., Ichikawa, H., Kurisu, K., Wakisaka, S., Kiyomiya, K., Kurebe, M. Anat. Rec. (1993) [Pubmed]
  13. Amino acid sequences of double-headed proteinase inhibitors from the seeds of Canavalia lineata. Terada, S., Fujimura, S., Kimoto, E. Biosci. Biotechnol. Biochem. (1994) [Pubmed]
  14. Genomic structure of ornithine carbamoyltransferase gene from Canavalia lineata. Lee, Y., Yoo, S.K., Lee, J.S., Kwon, Y.M. Mol. Cells (2000) [Pubmed]
  15. Native crystal structure of a nitric oxide-releasing lectin from the seeds of Canavalia maritima. Gadelha, C.A., Moreno, F.B., Santi-Gadelha, T., Cajazeiras, J.B., Rocha, B.A., Assreuy, A.M., Lima Mota, M.R., Pinto, N.V., Passos Meireles, A.V., Borges, J.C., Freitas, B.T., Canduri, F., Souza, E.P., Delatorre, P., Criddle, D.N., de Azevedo, W.F., Cavada, B.S. J. Struct. Biol. (2005) [Pubmed]
  16. Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume. Jeon, K.S., Na, H.J., Kim, Y.M., Kwon, H.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  17. Changes in En(a-) human red blood cell membranes during in vivo ageing. Shinozuka, T., Miyata, Y., Takei, S., Yoshida, R., Ogamo, A., Nakagawa, Y., Kuroda, N., Yanagida, J. Mech. Ageing Dev. (1996) [Pubmed]
  18. Lectin-induced histamine release from various populations of hamster mast cells. Wyczólkowska, J., Prouvost, A., Rydzyński, K. Agents Actions (1988) [Pubmed]
  19. Lectin binding characteristics of squamous cell carcinomas of the head and neck. Lalwani, A.K., Carey, T.E., Goldstein, I.J., Peters, B.P. Acta Otolaryngol. (1996) [Pubmed]
  20. A convenient method of preparation of high-activity urease from Canavalia ensiformis by covalent chromatography and an investigation of its thiol groups with 2,2'-dipyridyl disulphide as a thiol titrant and reactivity probe. Norris, R., Brocklehurst, K. Biochem. J. (1976) [Pubmed]
  21. A study of maturation events in jackbeans (Canavalia ensiformis). Marcus, S.E., Burgess, J., Maycox, P.R., Bowles, D.J. Biochem. J. (1984) [Pubmed]
  22. Recognition of novel amphiphiles with many pendent mannose residues by Con A. Tagawa, K., Sendai, N., Ohno, K., Kawaguchi, T., Kitano, H., Matsunaga, T. Bioconjug. Chem. (1999) [Pubmed]
  23. L-canavanine influences feed intake, plasma basic amino acid concentrations and kidney arginase activity in chicks. Michelangeli, C., Vargas, R.E. J. Nutr. (1994) [Pubmed]
  24. Characterization of the binding of the TC-83 strain of Venezuelan Equine encephalomyelitis virus to BW-J-M, a mouse macrophage-like cell line. Huggins, J.W., Jahrling, P.B., Rill, W., Linden, C.D. J. Gen. Virol. (1983) [Pubmed]
  25. An analysis of the morphology of senile plaques in Down's syndrome patients of different ages using immunocytochemical and lectin histochemical techniques. Mann, D.M., Brown, A., Prinja, D., Davies, C.A., Landon, M., Masters, C.L., Beyreuthers, K. Neuropathol. Appl. Neurobiol. (1989) [Pubmed]
  26. cDNA cloning of two isoforms of ornithine carbamoyltransferase from Canavalia lineata leaves and the effect of site-directed mutagenesis of the carbamoyl phosphate binding site. Lee, Y., Choi, Y.A., Hwang, I.D., Kim, S.G., Kwon, Y.M. Plant Mol. Biol. (2001) [Pubmed]
  27. Analysis of lectin- and snail plasma-binding glycopeptides associated with the tegumental surface of the primary sporocysts of Schistosoma mansoni. Johnston, L.A., Yoshino, T.P. Parasitology (1996) [Pubmed]
  28. Medicinal foodstuffs. XIX. Absolute stereostructures of canavalioside, a new Ent-kaurane-type diterpene glycoside, and gladiatosides A1, A2, A3, B1, B2, B3, C1, and C2, new acylated flavonol glycosides, from sword bean, the seeds of Canavalia gladiata. Murakami, T., Kohno, K., Kishi, A., Matsuda, H., Yoshikawa, M. Chem. Pharm. Bull. (2000) [Pubmed]
  29. Purification and characterization of Canavalia gladiata agglutinin. Kojima, K., Ogawa, H., Seno, N., Matsumoto, I. Carbohydr. Res. (1991) [Pubmed]
  30. Mechanism of cleavage at Asn 148 during the maturation of jack bean concanavalin A. Brennan, T.V., Clarke, S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  31. Purification and characterization of two Kunitz family subtilisin inhibitors from seeds of Canavalia lineata. Terada, S., Fujimura, S., Katayama, H., Nagasawa, M., Kimoto, E. J. Biochem. (1994) [Pubmed]
  32. Complete amino acid sequences of three proteinase inhibitors from white sword bean (Canavalia gladiata). Park, S.S., Sumi, T., Ohba, H., Nakamura, O., Kimura, M. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  33. Normal protein and glycoprotein profiles of reflex tears and trace element composition of basal tears from heavy and slight deposits on soft contact lenses. Baguet, J., Claudon-Eyl, V., Sommer, F., Chevallier, P. The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc. (1995) [Pubmed]
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