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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.

Stimulation of phosphatidylinositol-4,5-bisphosphate (PIP2) hydrolysis is a widespread mechanism for receptor-mediated signaling in eukaryotes. Cytosolic phosphatidylinositol transfer protein (PITP) is necessary for guanosine triphosphate (GTP)-dependent hydrolysis of PIP2 by phospholipase C-beta ( PLC-beta), but the role of PITP is unclear. Stimulation of phospholipase C-gamma ( PLC-gamma) in A431 human epidermoid carcinoma cells treated with epidermal growth factor (EGF) required PITP. Stimulation of PI-4 kinase in cells treated with EGF also required PITP. Coprecipitation studies revealed an EGF-dependent association of PITP with the EGF receptor, with PI-4 kinase, and with PLC-gamma.[1]


  1. Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling. Kauffmann-Zeh, A., Thomas, G.M., Ball, A., Prosser, S., Cunningham, E., Cockcroft, S., Hsuan, J.J. Science (1995) [Pubmed]
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