The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SERPINA4  -  serpin peptidase inhibitor, clade A (alpha...

Homo sapiens

Synonyms: KAL, KLST, KST, Kallikrein inhibitor, Kallistatin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SERPINA4


Psychiatry related information on SERPINA4


High impact information on SERPINA4


Chemical compound and disease context of SERPINA4


Biological context of SERPINA4


Anatomical context of SERPINA4


Associations of SERPINA4 with chemical compounds


Physical interactions of SERPINA4


Regulatory relationships of SERPINA4


Other interactions of SERPINA4


Analytical, diagnostic and therapeutic context of SERPINA4


  1. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. Chai, K.X., Chen, L.M., Chao, J., Chao, L. J. Biol. Chem. (1993) [Pubmed]
  2. Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy. Ma, J.X., King, L.P., Yang, Z., Crouch, R.K., Chao, L., Chao, J. Curr. Eye Res. (1996) [Pubmed]
  3. Intestinal tissue kallikrein-kallistatin profile in inflammatory bowel disease. Stadnicki, A., Mazurek, U., Plewka, D., Wilczok, T. Int. Immunopharmacol. (2003) [Pubmed]
  4. Kallistatin is a potent new vasodilator. Chao, J., Stallone, J.N., Liang, Y.M., Chen, L.M., Wang, D.Z., Chao, L. J. Clin. Invest. (1997) [Pubmed]
  5. Effects of Alzheimer's disease-related beta amyloid protein fragments on enzymes metabolizing phosphoinositides in brain. Wallace, M.A. Biochim. Biophys. Acta (1994) [Pubmed]
  6. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. Han, E.D., MacFarlane, R.C., Mulligan, A.N., Scafidi, J., Davis, A.E. J. Clin. Invest. (2002) [Pubmed]
  7. Molecular cloning and expression of rat kallistatin gene. Chai, K.X., Chen, V.C., Ni, A., Lindpaintner, K., Rubattu, S., Chao, L., Chao, J. Biochim. Biophys. Acta (1997) [Pubmed]
  8. Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells. Shiotsuka, S., Isonishi, S. Int. J. Oncol. (2001) [Pubmed]
  9. Kallikrein-kinin system activation by Lonomia obliqua caterpillar bristles: Involvement in edema and hypotension responses to envenomation. Bohrer, C.B., Reck Junior, J., Fernandes, D., Sordi, R., Guimarães, J.A., Assreuy, J., Termignoni, C. Toxicon (2007) [Pubmed]
  10. Studies on the natriuretic effect of nifedipine in hypertensive patients: increase in levels of plasma atrial natriuretic factor without participation of the renal kallikrein-kinin system. Rappelli, A., Dessì-Fulgheri, P., Madeddu, P., Glorioso, N. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. (1987) [Pubmed]
  11. Roles of the P1, P2, and P3 residues in determining inhibitory specificity of kallistatin toward human tissue kallikrein. Chen, V.C., Chao, L., Chao, J. J. Biol. Chem. (2000) [Pubmed]
  12. Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands. Wolf, W.C., Harley, R.A., Sluce, D., Chao, L., Chao, J. Histochem. Cell Biol. (1998) [Pubmed]
  13. Cellular localization of tissue kallikrein and kallistatin mRNAs in human kidney. Chen, L.M., Song, Q., Chao, L., Chao, J. Kidney Int. (1995) [Pubmed]
  14. Identification of a major heparin-binding site in kallistatin. Chen, V.C., Chao, L., Pimenta, D.C., Bledsoe, G., Juliano, L., Chao, J. J. Biol. Chem. (2001) [Pubmed]
  15. Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence. Zhou, G.X., Chao, L., Chao, J. J. Biol. Chem. (1992) [Pubmed]
  16. Inactivation of kallikrein in human plasma. van der Graaf, F., Koedam, J.A., Bouma, B.N. J. Clin. Invest. (1983) [Pubmed]
  17. Progressive inhibition of human glandular (urinary) kallikrein by human serum and identification of the progressive antikallikrein as alpha 1-antitrypsin (alpha 1-protease inhibitor). Geiger, R., Stuckstedte, U., Clausnitzer, B., Fritz, H. Hoppe-Seyler's Z. Physiol. Chem. (1981) [Pubmed]
  18. A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein. Chen, V.C., Chao, L., Chao, J. J. Biol. Chem. (2000) [Pubmed]
  19. Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda: Isolation and characterization. Kita, M., Nakamura, Y., Okumura, Y., Ohdachi, S.D., Oba, Y., Yoshikuni, M., Kido, H., Uemura, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. Kallistatin is a new inhibitor of angiogenesis and tumor growth. Miao, R.Q., Agata, J., Chao, L., Chao, J. Blood (2002) [Pubmed]
  21. Structural elements of kallistatin required for inhibition of angiogenesis. Miao, R.Q., Chen, V., Chao, L., Chao, J. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  22. Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans. Campbell, D.J., Dixon, B., Kladis, A., Kemme, M., Santamaria, J.D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
WikiGenes - Universities