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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11.

Cleft lip with or without cleft palate, CL(P), a common human birth defect, has a genetically complex etiology. An animal model with a similarly complex genetic basis is established in the A/WySn mouse strain, in which 20% of newborns have CL(P). Using a newly created congenic strain, AEJ.A, and SSLP markers, we have mapped a major CL(P)-causing gene derived from the A/WySn strain. This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus.[1]

References

  1. The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11. Juriloff, D.M., Mah, D.G. Mamm. Genome (1995) [Pubmed]
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