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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25.

A human clone corresponding to the homologue of the murine Polycomb-like gene M33 has been used to map this gene (CBX2) to human chromosomes. Both somatic cell hybrid panels and FISH on metaphase chromosomes have been used. These techniques gave a consistent localization, at the tip of the long arm of chromosome 17 (17q25). This localization, as well as the potential role of a mammalian Polycomb-like protein, suggests a potential involvement in two different pathologies: the campomelic syndrome, an inherited disorder, and neoplastic disorders linked to allele loss already described in this region.[1]

References

  1. Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25. Gecz, J., Gaunt, S.J., Passage, E., Burton, R.D., Cudrey, C., Pearce, J.J., Fontes, M. Genomics (1995) [Pubmed]
 
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