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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Growth-related coordinate regulation of the early N-glycosylation genes in yeast.

The Saccharomyces cerevisiae ALG7, ALG1 and ALG2 genes, whose products function early in the dolichol pathway of protein N-glycosylation, are essential for cell viability, and perturbation in their expression causes G1-specific cell cycle arrest. Here, we show that expression of the ALG7, ALG1 and ALG2 genes is coordinately regulated at the G0/G1 transition point in the yeast life cycle. Carbon starvation, which induces cells to exit from the G1 stage of the mitotic cycle into G0, resulted in a time-dependent decrease in the levels of the early ALG genes' mRNAs. Accordingly, addition of glucose, which stimulates the G0-arrested cells to resume proliferation, resulted in a rapid induction of their mRNAs. Cycloheximide alone also induced the early ALG transcripts, albeit to a much lower extent than glucose. Simultaneous addition of glucose and cycloheximide caused superinduction of these mRNAs, indicating that more than one control level was involved in their activation. Consistent with this, rapid degradation of ALG7, ALG1 and ALG2 mRNAs was completely abolished in the presence of cycloheximide. These data suggest that in yeast, the early N-glycosylation genes are regulated in a manner similar to that of the early growth-response genes.[1]


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