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Gene Review

ALG7  -  UDP-N-acetylglucosamine--dolichyl...

Saccharomyces cerevisiae S288c

Synonyms: G1PT, GPT, GlcNAc-1-P transferase, N-acetylglucosamine-1-phosphate transferase, TUR1, ...
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Disease relevance of ALG7


High impact information on ALG7

  • Expression of the coding region of the GPT in transformed yeast cells and subsequent transport experiments with the purified protein demonstrated that the GPT protein mediates a 1:1 exchange of glucose 6-phosphate mainly with inorganic phosphate and triose phosphates [2].
  • Glucose 6-phosphate imported via the GPT can thus be used either for starch biosynthesis, during which process inorganic phosphate is released, or as a substrate for the oxidative pentose phosphate pathway, yielding triose phosphates [2].
  • Analysis of the primary sequences of the cDNAs revealed that the GPT proteins have a high degree of identity with each other but share only approximately 38% identical amino acids with members of both the triose phosphate/phosphate translocator (TPT) and the phosphoenolpyruvate/phosphate translocator (PPT) families [2].
  • (ii) The ALG7 and DPM1 proteins are known to recognize the isoprenoid region of dolichol phosphate specifically; this recognition presumably occurs in the membrane since dolichol is very hydrophobic [3].
  • Protein glycosylation in yeast: transcript heterogeneity of the ALG7 gene [4].

Biological context of ALG7


Anatomical context of ALG7


Associations of ALG7 with chemical compounds


Analytical, diagnostic and therapeutic context of ALG7


  1. Asparagine-linked glycosylation in Schizosaccharomyces pombe: functional conservation of the first step in oligosaccharide-lipid assembly. Zou, J., Scocca, J.R., Krag, S.S. Arch. Biochem. Biophys. (1995) [Pubmed]
  2. Molecular characterization of a carbon transporter in plastids from heterotrophic tissues: the glucose 6-phosphate/phosphate antiporter. Kammerer, B., Fischer, K., Hilpert, B., Schubert, S., Gutensohn, M., Weber, A., Flügge, U.I. Plant Cell (1998) [Pubmed]
  3. A 13-amino acid peptide in three yeast glycosyltransferases may be involved in dolichol recognition. Albright, C.F., Orlean, P., Robbins, P.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Protein glycosylation in yeast: transcript heterogeneity of the ALG7 gene. Kukuruzinska, M.A., Robbins, P.W. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  5. Deregulation of the first N-glycosylation gene, ALG7, perturbs the expression of G1 cyclins and cell cycle arrest in Saccharomyces cerevisiae. Lennon, K., Bird, A., Kukuruzinska, M.A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  6. Asparagine-linked glycosylation in Saccharomyces cerevisiae: genetic analysis of an early step. Barnes, G., Hansen, W.J., Holcomb, C.L., Rine, J. Mol. Cell. Biol. (1984) [Pubmed]
  7. Proliferation-dependent differential regulation of the dolichol pathway genes in Saccharomyces cerevisiae. Lennon, K., Pretel, R., Kesselheim, J., te Heesen, S., Kukuruzinska, M.A. Glycobiology (1995) [Pubmed]
  8. Growth-related coordinate regulation of the early N-glycosylation genes in yeast. Kukuruzinska, M.A., Lennon, K. Glycobiology (1994) [Pubmed]
  9. Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae. Eckert, V., Blank, M., Mazhari-Tabrizi, R., Mumberg, D., Funk, M., Schwarz, R.T. Glycobiology (1998) [Pubmed]
  10. Characterization of multiple transcripts of the hamster dolichol-P-dependent N-acetylglucosamine-1-P transferase suggests functionally complex expression. Huang, G.T., Lennon, K., Kukuruzinska, M.A. Mol. Cell. Biochem. (1998) [Pubmed]
  11. Diminished activity of the first N-glycosylation enzyme, dolichol-P-dependent N-acetylglucosamine-1-P transferase (GPT), gives rise to mutant phenotypes in yeast. Kukuruzinska, M.A., Lennon, K. Biochim. Biophys. Acta (1995) [Pubmed]
  12. The dual role of mRNA half-lives in the expression of the yeast ALG7 gene. Lennon, K., Bird, A., Chen, Y.F., Pretel, R., Kukuruzinska, M.A. Mol. Cell. Biochem. (1997) [Pubmed]
  13. A hypomorphic allele of the first N-glycosylation gene, ALG7, causes mitochondrial defects in yeast. Mendelsohn, R.D., Helmerhorst, E.J., Cipollo, J.F., Kukuruzinska, M.A. Biochim. Biophys. Acta (2005) [Pubmed]
  14. Sequence of a cDNA that specifies the uridine diphosphate N-acetyl-D-glucosamine:dolichol phosphate N-acetylglucosamine-1-phosphate transferase from Chinese hamster ovary cells. Scocca, J.R., Krag, S.S. J. Biol. Chem. (1990) [Pubmed]
  15. Molecular dissection of the genetic targets of ALG7 in the serpentine receptor-mediated signal transduction pathway in yeast. Lennon, K., Bird, A., Kukuruzinska, M.A. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  16. Amplification and molecular cloning of the hamster tunicamycin-sensitive N-acetylglucosamine-1-phosphate transferase gene. The hamster and yeast enzymes share a common peptide sequence. Lehrman, M.A., Zhu, X.Y., Khounlo, S. J. Biol. Chem. (1988) [Pubmed]
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