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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Curcacycline A--a novel cyclic octapeptide isolated from the latex of Jatropha curcas L.

From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly1-Leu2-Leu3-Gly4-Thr5-Val6-Leu7-Leu8-Gly1+ ++. Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.[1]

References

  1. Curcacycline A--a novel cyclic octapeptide isolated from the latex of Jatropha curcas L. van den Berg, A.J., Horsten, S.F., Kettenes-van den Bosch, J.J., Kroes, B.H., Beukelman, C.J., Leeflang, B.R., Labadie, R.P. FEBS Lett. (1995) [Pubmed]
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