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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.

A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a Ki of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.[1]

References

  1. Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L. Takeda, A., Yamamoto, T., Nakamura, Y., Takahashi, T., Hibino, T. FEBS Lett. (1995) [Pubmed]
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