The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SERPINB3  -  serpin peptidase inhibitor, clade B...

Homo sapiens

Synonyms: HsT1196, Protein T4-A, SCC, SCCA, SCCA-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SERPINB3


Psychiatry related information on SERPINB3


High impact information on SERPINB3


Chemical compound and disease context of SERPINB3


Biological context of SERPINB3


Anatomical context of SERPINB3


Associations of SERPINB3 with chemical compounds


Regulatory relationships of SERPINB3

  • Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression [28].
  • These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells [29].
  • Recombinant SCC antigen-2 inhibits cathepsin G and mast cell chymase, suggesting that it protects epithelial cells from the inflammation induced by these proteases [30].

Other interactions of SERPINB3


Analytical, diagnostic and therapeutic context of SERPINB3

  • We studied the relative levels of SCCA2 and SCCA1 mRNA in frozen sections of squamous cell carcinomas of the head and neck (SCCHN) in relation to disease recurrence, using a new reverse transcription-polymerase chain reaction-based technique for accurate quantitation of relative mRNA levels [2].
  • Squamous cell carcinoma antigen was evaluated by immunohistochemistry in 65 HCCs of different aetiology and in 20 normal livers [32].
  • Using a new set of discriminatory monoclonal antibodies (MAbs) and polymerase chain reaction (PCR) assay, we showed that SCCA1 and SCCA2 were co-expressed in the suprabasal layers of the stratified squamous epithelium of the tongue, tonsil, esophagus, uterine cervix and vagina, Hassall's corpuscles of the thymus, and some areas of the skin [35].
  • These results suggest that the level of expression of SCCA2 mRNA detected by RT-PCR can be used to evaluate the status of SCC tumors [36].
  • Western blot analysis showed that the levels of these two SCC-Ag proteins in SCCMM were 15-fold higher than those in CaSki, suggesting that expression of the SCC-Ag in SCCMM was controlled at both the transcriptional and post-transcriptional levels [37].


  1. Overexpression of serpin squamous cell carcinoma antigens in psoriatic skin. Takeda, A., Higuchi, D., Takahashi, T., Ogo, M., Baciu, P., Goetinck, P.F., Hibino, T. J. Invest. Dermatol. (2002) [Pubmed]
  2. Relative levels of SCCA2 and SCCA1 mRNA in primary tumors predicts recurrent disease in squamous cell cancer of the head and neck. Stenman, J., Hedström, J., Grénman, R., Leivo, I., Finne, P., Palotie, A., Orpana, A. Int. J. Cancer (2001) [Pubmed]
  3. Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. Hamada, K., Shinomiya, H., Asano, Y., Kihana, T., Iwamoto, M., Hanakawa, Y., Hashimoto, K., Hirose, S., Kyo, S., Ito, M. Biochim. Biophys. Acta (2001) [Pubmed]
  4. Preoperative serum squamous cell carcinoma antigen levels in clinical decision making for patients with early-stage cervical cancer. Reesink-Peters, N., van der Velden, J., Ten Hoor, K.A., Boezen, H.M., de Vries, E.G., Schilthuis, M.S., Mourits, M.J., Nijman, H.W., Aalders, J.G., Hollema, H., Pras, E., Duk, J.M., van der Zee, A.G. J. Clin. Oncol. (2005) [Pubmed]
  5. Role of macronutrients, vitamins and minerals in the aetiology of squamous-cell carcinoma of the oesophagus. Franceschi, S., Bidoli, E., Negri, E., Zambon, P., Talamini, R., Ruol, A., Parpinel, M., Levi, F., Simonato, L., La Vecchia, C. Int. J. Cancer (2000) [Pubmed]
  6. Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. Sato, M., Sato, T., Izumo, T., Amagasa, T. Carcinogenesis (1999) [Pubmed]
  7. Are squamous and adenocarcinomas of the esophagus the same disease? Siewert, J.R., Ott, K. Seminars in radiation oncology (2007) [Pubmed]
  8. Cutaneous manifestations of chronic arsenicism: review of seventeen cases. Wong, S.S., Tan, K.C., Goh, C.L. J. Am. Acad. Dermatol. (1998) [Pubmed]
  9. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. Czubayko, F., Liaudet-Coopman, E.D., Aigner, A., Tuveson, A.T., Berchem, G.J., Wellstein, A. Nat. Med. (1997) [Pubmed]
  10. Sunburn and p53 in the onset of skin cancer. Ziegler, A., Jonason, A.S., Leffell, D.J., Simon, J.A., Sharma, H.W., Kimmelman, J., Remington, L., Jacks, T., Brash, D.E. Nature (1994) [Pubmed]
  11. Paraneoplastic myasthenic syndrome IgG inhibits 45Ca2+ flux in a human small cell carcinoma line. Roberts, A., Perera, S., Lang, B., Vincent, A., Newsom-Davis, J. Nature (1985) [Pubmed]
  12. Identification of squamous cell carcinoma antigen-2 in tumor tissue by two-dimensional electrophoresis. Nawata, S., Murakami, A., Hirabayashi, K., Sakaguchi, Y., Ogata, H., Suminami, Y., Numa, F., Nakamura, K., Kato, H. Electrophoresis (1999) [Pubmed]
  13. Risk of basal cell and squamous cell skin cancers after ionizing radiation therapy. For The Skin Cancer Prevention Study Group. Karagas, M.R., McDonald, J.A., Greenberg, E.R., Stukel, T.A., Weiss, J.E., Baron, J.A., Stevens, M.M. J. Natl. Cancer Inst. (1996) [Pubmed]
  14. Examining the role of mitochondrial respiration in vanilloid-induced apoptosis. Hail, N., Lotan, R. J. Natl. Cancer Inst. (2002) [Pubmed]
  15. Cell proliferation in human cutaneous squamous cell carcinoma. Friedland, A.M., Weinstein, G.D. J. Natl. Cancer Inst. (1977) [Pubmed]
  16. Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours. Heagerty, A.H., Fitzgerald, D., Smith, A., Bowers, B., Jones, P., Fryer, A.A., Zhao, L., Alldersea, J., Strange, R.C. Lancet (1994) [Pubmed]
  17. Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase. Katagiri, C., Nakanishi, J., Kadoya, K., Hibino, T. J. Cell Biol. (2006) [Pubmed]
  18. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Schneider, S.S., Schick, C., Fish, K.E., Miller, E., Pena, J.C., Treter, S.D., Hui, S.M., Silverman, G.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase. Schick, C., Kamachi, Y., Bartuski, A.J., Cataltepe, S., Schechter, N.M., Pemberton, P.A., Silverman, G.A. J. Biol. Chem. (1997) [Pubmed]
  20. Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Askew, D.J., Askew, Y.S., Kato, Y., Turner, R.F., Dewar, K., Lehoczky, J., Silverman, G.A. Genomics (2004) [Pubmed]
  21. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Uemura, Y., Pak, S.C., Luke, C., Cataltepe, S., Tsu, C., Schick, C., Kamachi, Y., Pomeroy, S.L., Perlmutter, D.H., Silverman, G.A. Int. J. Cancer (2000) [Pubmed]
  22. Squamous cell carcinoma antigen suppresses radiation-induced cell death. Murakami, A., Suminami, Y., Hirakawa, H., Nawata, S., Numa, F., Kato, H. Br. J. Cancer (2001) [Pubmed]
  23. Tumor-associated serpin, squamous cell carcinoma antigen stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines. Sueoka, K., Nawata, S., Nakagawa, T., Murakami, A., Takeda, O., Suminami, Y., Kato, H., Sugino, N. Int. J. Oncol. (2005) [Pubmed]
  24. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Schick, C., Pemberton, P.A., Shi, G.P., Kamachi, Y., Cataltepe, S., Bartuski, A.J., Gornstein, E.R., Brömme, D., Chapman, H.A., Silverman, G.A. Biochemistry (1998) [Pubmed]
  25. Transient increase in squamous cell carcinoma antigen expression in cultured cervical carcinoma CaSki cells in response to exposure to cis-diamminedichloroplatinum. Tateiwa, Y., Yoshida, S., Miyahara, Y., Hamana, S., Motoyama, S., Maruo, T. Tumour Biol. (2003) [Pubmed]
  26. Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma. Anttila, T., Saikku, P., Koskela, P., Bloigu, A., Dillner, J., Ikäheimo, I., Jellum, E., Lehtinen, M., Lenner, P., Hakulinen, T., Närvänen, A., Pukkala, E., Thoresen, S., Youngman, L., Paavonen, J. JAMA (2001) [Pubmed]
  27. Smoking and other risk factors for lung cancer in women. Wu, A.H., Henderson, B.E., Pike, M.C., Yu, M.C. J. Natl. Cancer Inst. (1985) [Pubmed]
  28. Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression. Murakami, A., Nakagawa, T., Kaneko, M., Nawata, S., Takeda, O., Kato, H., Sugino, N. Int. J. Oncol. (2006) [Pubmed]
  29. Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L. Takeda, A., Yamamoto, T., Nakamura, Y., Takahashi, T., Hibino, T. FEBS Lett. (1995) [Pubmed]
  30. Biological role of SCC antigen. Suminami, Y., Nawata, S., Kato, H. Tumour Biol. (1998) [Pubmed]
  31. Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1. Masumoto, K., Sakata, Y., Arima, K., Nakao, I., Izuhara, K. J. Biol. Chem. (2003) [Pubmed]
  32. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. Pontisso, P., Calabrese, F., Benvegnù, L., Lise, M., Belluco, C., Ruvoletto, M.G., Marino, M., Valente, M., Nitti, D., Gatta, A., Fassina, G. Br. J. Cancer (2004) [Pubmed]
  33. Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line. Hirakawa, H., Nawata, S., Sueoka, K., Murakami, A., Takeda, O., Numa, F., Kato, H., Sugino, N. Oncol. Rep. (2004) [Pubmed]
  34. Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues. Nawata, S., Nakamura, K., Hirakawa, H., Sueoka, K., Emoto, T., Murakami, A., Umayahara, K., Ogata, H., Suminami, Y., Numa, F., Kato, H. Electrophoresis (2003) [Pubmed]
  35. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. Cataltepe, S., Gornstein, E.R., Schick, C., Kamachi, Y., Chatson, K., Fries, J., Silverman, G.A., Upton, M.P. J. Histochem. Cytochem. (2000) [Pubmed]
  36. Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis. Takeda, A., Kajiya, A., Iwasawa, A., Nakamura, Y., Hibino, T. Biol. Chem. (2002) [Pubmed]
  37. Overexpression of SCC antigen and cyclins in an adenoid squamous carcinoma cell line derived from the maxillary sinus. Kishimoto, H., Urade, M., Hashimoto-Tamaoki, T., Furuyama, J.I. Int. J. Oncol. (2001) [Pubmed]
WikiGenes - Universities