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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Phase II trial of piroxantrone in metastatic gastric adenocarcinoma.

Piroxantrone, a synthetic intercalating agent, was studied in patients with advanced, measurable gastric adenocarcinoma who had not received prior chemotherapy. The starting piroxantrone dose was 150 mg/m2 given intravenously over 1 hour on day 1 and repeated every 21 days. Response and toxicity could be evaluated in 15 patients. No complete, partial, or minor responses were observed. Toxic effects included granulocytopenia, anemia, vomiting, nausea, anorexia, fatigue, stomatitis, alopecia, hyperbilirubinemia, and increased alkaline phosphatase levels. At the stated dose and schedule, piroxantrone does not possess significant activity against advanced gastric cancer.[1]

References

  1. Phase II trial of piroxantrone in metastatic gastric adenocarcinoma. Pazdur, R., Bready, B., Scalzo, A.J., Brandof, J.E., Close, D.R., Kolbye, S., Winn, R.J. Investigational new drugs. (1994) [Pubmed]
 
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