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Peyrard, M. et al.

Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.

A 140 kb homozygous deletion from 22q12 in one meningioma directed us towards the cloning and characterization of a new member of the human beta-adaptin gene family (named BAM22). Adaptins are essential for the formation of clathrin coated vesicles in the course of intracellular transport of receptor-ligand complexes. The BAM22 gene is totally inactivated in the tumor with homozygous deletion. Northern blot analysis of 70 sporadic meningiomas showed specific loss of expression in 8 tumors, suggesting inactivation of BAM22. Based on this, we propose BAM22 as a second chromosome 22 locus important in meningioma development, after the neurofibromatosis type 2 gene.[1]

References

Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Peyrard, M., Fransson, I., Xie, Y.G., Han, F.Y., Ruttledge, M.H., Swahn, S., Collins, J.E., Dunham, I., Collins, V.P., Dumanski, J.P. Hum. Mol. Genet. (1994) [Pubmed]

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